ADP-Ribosylating Toxins

  • Klaus Aktories

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 175)

Table of contents

  1. Front Matter
    Pages I-X
  2. I. H. Madshus, H. Stenmark
    Pages 1-26
  3. K. Aktories, M. Wille, I. Just
    Pages 97-113
  4. K. Aktories, C. Mohr, G. Koch
    Pages 115-131
  5. J. Coburn
    Pages 133-143
  6. Back Matter
    Pages 145-150

About this book

Introduction

ADP-ribosylating toxins have been the focus of intensive research for more than 30 years. Researchers from diverse fields of science have taken an interest in these bacterial toxins; they are studied, for example, by microbiologists, biochemists, cell biologists, and pharmacologists. There are two principal reasons for the broad and still growing interest in ADP­ ribosylating toxins. First, insights into the structure and functions of the toxins might be the key to prevention and treatment of diseases caused by the toxin-producing infectious micro­ organisms. Second, the ADP-ribosylating toxins provide potent and often unique pharmacological tools for the study of the physiological functions of their target proteins. The latter is especially the case with cholera and pertussis toxins, which both modify the IX-subunits of heterotrimeric G-proteins involved in signal transduction pathways. These toxins have proved invaluable in extending our basic understanding of the regulation of hormone-controlled signal transduction. This volume provides a review and an update of recent studies on the basic properties of bacterial ADP-ribosylating tbxins and/or exoenzymes. Our current knowledge of the cel­ lular entry mechanisms of ADP-ribosylating toxins is reviewed by MADSHUS and STENMARK. WILSON and COLLIER then deal with recent insights into the enzyme mechanism and active site structure of diphtheria toxin and Pseudomonas aeruginosa exotoxin A, which modify elongation factor 2. Toxins which ADP-ribosylate heterotrimeric G-proteins involved in trans­ membrane signal transduction are the subject of the next two chapters.

Keywords

GTP-bindende Proteine Toxin, Cholera Toxin, Diphterie- Toxin, Pertussis- Toxine, bakterielle bacteria protein proteins pseudomonas toxin

Editors and affiliations

  • Klaus Aktories
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieUniversität des SaarlandsHomburg/saarGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-76966-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-76968-9
  • Online ISBN 978-3-642-76966-5
  • Series Print ISSN 0070-217X
  • About this book