Transdermal Fentanyl

A New Approach to Prolonged Pain Control

  • Klaus A. Lehmann
  • Detlev Zech

Table of contents

  1. Front Matter
    Pages I-XI
  2. Transdermal Therapeutic Systems — An Introduction

    1. Front Matter
      Pages XIII-XIII
    2. S. S. Hwang, K. C. Nichols, M. Southam
      Pages 1-7
  3. Current Aspects of Pain Management

    1. Front Matter
      Pages 15-15
    2. K. A. Lehmann, S. Grond, D. Zech
      Pages 17-35
    3. R. Payne
      Pages 36-41
    4. C. M. Moinpour, C. R. Chapman
      Pages 42-63
    5. M. Strumpf, M. Zenz
      Pages 64-70
  4. Noninvasive Fentanyl Application

    1. Front Matter
      Pages 71-71
    2. L. E. Mather, G. K. Gourlay
      Pages 73-97
    3. M. Southam, S. Gupta, M. Knowles, S. S. Hwang
      Pages 107-116
  5. Postoperative Pain Management with TTS Fentanyl

    1. Front Matter
      Pages 117-117
    2. G. K. Gourlay, L. E. Mather
      Pages 119-140
    3. B. von Borman
      Pages 141-148
    4. L. Latasch, R. Christ
      Pages 149-157
    5. C. Einnolf, H. J. Eberlein, K. A. Lehmann
      Pages 158-167
  6. Cancer Pain Management with TTS Fentanyl

    1. Front Matter
      Pages 169-169
    2. D. Zech, S. Grond, J. Lynch
      Pages 171-187
  7. Other Transdermal Therapeutic Systems for Anesthesia and Pain Management

    1. Front Matter
      Pages 189-189
    2. I. Tigerstedt
      Pages 195-200
  8. Back Matter
    Pages 201-203

About these proceedings


That pain is a serious clinical problem, which requires considerable effortsby physicians and the nursing staff, has been stressed in numerous publications. Transdermal application is well known for a variety of drugs, including cardiovascular drugs, antiemetics and hormones. Some years ago, first experience was also made with transdermally administered opiates from which the transdermal therapeutic system (TTS) fentanyl has now been approved by the American Food and Drug Administration. The book presents the results of the first international workshop "Transdermal Fentanyl", held September 27 -28, 1990 in Cologne, FRG. This workshop was intended to facilitate a critical evaluation of theoretical and clinical studies with the new, non-invasive fentanyl application and to provide an opportunity for an exchange of ideas about its value for pain management, anaesthesiology and future investigations in this field. Topics covered by the book are physiology of transdermal permeation, experience with other transdermal systems, the present state of acute and chronic pain management and experimental and clinical studies with transdermal fentanyl, with special concern to analgesic efficacy and side effects. Readers will easily find out that the experts appreciated transdermal analgesia but also warned against an uncritical optimism. TTS fentanyl can be a valuable tool in the clinicians' armentarium against pain. It should be kept in mind, however, that it represents a new administration mode, not a new drug, and that the sustained, non-invasive application requires well reflected diagnosis and good general standards of pain management.


Analgesie Opiate Opiate analgesics Opioid Schmerzbekämpfung acute and chronic fentanyl Non-invasive administration physiology transdermal Pain management

Editors and affiliations

  • Klaus A. Lehmann
    • 1
  • Detlev Zech
    • 1
  1. 1.Institut für Anaesthesiologie und Operative IntensivmedizinUniversität KölnKöln 41Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-54440-1
  • Online ISBN 978-3-642-76872-9
  • Buy this book on publisher's site