Epidemiology and Biology of Multiple Myeloma

1. Front Matter

   Pages I-XV

   PDF

2. Descriptive and Analytical Epidemiology

   1. Front Matter

      Pages 1-1

      PDF

   2. Descriptive Epidemiology of Multiple Myeloma

      • S. S. Devesa

      Pages 3-12

   3. Epidemiologic Studies of Multiple Myeloma: Occupation and Radiation Effects

      • D. A. Riedel

      Pages 13-16

   4. Multiple Myeloma in Iowa Farmers

      • Leon F. Burmeister

      Pages 17-22

   5. Risk of Multiple Myeloma, Allergies and Agricultural Exposures

      • Richard P. Gallagher, Diane H. Skippen

      Pages 23-26

   6. Leads for Future Studies from a Case-Control Study of Occupational Exposures and Multiple Myeloma in Denmark

      • E. F. Heineman, J. Olsen, L. M. Pottern, M. R. Gomez, E. Raffn, A. Blair

      Pages 27-29

   7. Familial and Genetic Associations

      • A. F. Olshan

      Pages 31-39

3. Black/White Differences in Risk

   1. Front Matter

      Pages 41-41

      PDF

   2. Racial Variations in Immune Function and Hematological Parameters: Description of Study Design and Objectives

      • L. M. Brown, D. J. Tollerud, W. A. Blattner, R. N. Hoover

      Pages 43-44

   3. The Influence of Race on T-Cell Subset Distributions

      • David J. Tollerud, Linda Morris Brown, William A. Blattner, Robert N. Hoover

      Pages 45-49

   4. Investigating Risk Factors for Multiple Myeloma among Black and White Americans

      • L. M. Pottern

      Pages 51-53

   5. Race and Socioeconomic Status Differences in Multiple Myeloma Survival

      • C. S. Glover, J. Horm, G. Christenson

      Pages 55-60

   6. Use of Veterans Administration Data to Identify Possible Risk Factors for Multiple Myeloma among Blacks and Whites

      • Andrew Z. Keller

      Pages 61-68

   7. Multiple Myeloma in Sub-Sahara Africa

      • Robert J. Jacobson

      Pages 69-71

4. Monoclonal Gammopathies and Multiple Myeloma

   1. Front Matter

      Pages 73-73

      PDF

   2. Case Definition: Issues Related to Monoclonal Gammopathies and Multiple Myeloma

      • Robert A. Kyle

      Pages 75-81

   3. The Frequency of Monoclonal Gammopathy of Unknown Significance in Black and Caucasian Veterans in a Hospital Population

      • G. P. Schechter, N. Shoff, C. Chan, C. D. McManus, H. P. Hawley

      Pages 83-85

   4. Racial Differences in the Expression of Shared Idiotypes by Paraproteins from Patients with Monoclonal Gammopathies

      • J. R. Berenson, A. K. Lichtenstein, J. Cao, S. Hart, D. Palomares, R. A. Miller

      Pages 87-96

5. Etiologic Hypotheses

   1. Front Matter

      Pages 98-98

      PDF

On March 27, 1990, the National Cancer Institute sponsored a workshop on the epidemiology of multiple myeloma, held at the National Institutes of Health. This book comprises articles prepared by participants in this work­ shop. Discussed in these papers are: the descriptive and analytic epidemi­ ology, differences in risk factors between blacks and whites, monoclonal gammopathies and their progression, and hypotheses regarding the etiology and pathogenesis of multiple myeloma. Several epidemiologic research areas received particular attention during this workshop, and are reviewed in detail in this volume. There have been striking increases in the incidence of multiple myeloma over the past thirty years, especially among older individuals and blacks, which may not be entirely explained by changes in diagnostic capabilities. Occupational and environmental exposures have been associated with an increased risk of multiple myeloma, including farming exposures, occupational exposure to petroleum and rubber processing, exposure to ionizing radiation, and asso­ ciations with persistent virus infections. The most striking epidemiological finding is reflected in the differences in incidence rates of multiple myeloma which are twice as high in blacks as compared with whites. Further, since 1950 the mortality rates for multiple myeloma have quadrupled in blacks while doubling for whites. Among hematopoietic malignancies, multiple myeloma is the only one with increased incidence and mortality rates among blacks. 1\vo major possibilities for explaining ethnic/racial differences in suscepti­ bility to multiple myeloma are genetic and environmental factors.

• Epidemiologie
• Etiologie
• Hematopoietic Cancer
• Multiple Myeloma
• Plasmozytom
• cancer
• cell
• cytogenetics
• epidemiology
• etiology
• genetics
• mortality
• pathogenesis
• plasma

• Epidemiology & Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, USA

  G. Iris Obrams

• Division of Cancer Biology, Diagnosis, and Centers, National Cancer Institute, Bethesda, USA

  Michael Potter

Policies and ethics