Transmissible Spongiform Encephalopathies:

Scrapie, BSE and Related Human Disorders

  • Bruce W. Chesebro

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 172)

Table of contents

  1. Front Matter
    Pages I-IX
  2. J. W. Wilesmith, G. A. H. Wells
    Pages 21-38
  3. D. C. Bolton, P. E. Bendheim
    Pages 39-55
  4. M. P. McKinley, S. B. Prusiner
    Pages 75-91
  5. B. Oesch, D. Westaway, S. B. Prusiner
    Pages 109-124
  6. M. E. Bruce, H. Fraser
    Pages 125-138
  7. R. J. Kascsak, R. Rubenstein, R. I. Carp
    Pages 139-152
  8. R. Race
    Pages 181-193
  9. S. B. Prusiner
    Pages 233-257
  10. Back Matter
    Pages 281-290

About this book

Introduction

In spite of a long history of intense investigation the transmissible spongiform encephalopathies remain a poorly understood family of neurodegenerative diseases. This group of diseases has been described in a wide variety of animal species and includes kuru, Creutzfeldt-Jakob disease, and Gerstmann-Straussler syndrome in humans, and scrapie, bovine spongiform encephalopathy, and related syndromes in ruminants and rodents. In all cases spongiform degeneration and astrocytosis are seen in specimens of brain and a filterable transmissible agent is present in the brain and some other tissues of affected individuals. However, the precise nature of this agent remains unknown. Agent infectivity, which can so far only be assayed by serial transmission to new individuals, be remarkably resistant to inactivation has been shown to by heat, chemicals, and irradiation. These properties create significant biohazard possibilities during exposure to infected tissues. Transmission between humans was originally reco­ gnized in the unique epidemiology of kuru in New Guinea tribesmen, and concern about transmission from animals to humans has re-emerged as a result of the current epidemic of bovine spongiform encephalopathy in dairy cattle in Great Britain. Although interspecies transmission has often been achieved experimentally, its efficiency is highly variable. There­ fore, the possibility of spread of bovine spongiform encephalopathy from cattle to humans or various animal populations cannot be accurately predicted at this time. This volume presents a comprehensive update of know­ ledge concerning the transmissible spongiform encephalo­ pathies.

Keywords

Enzephalopathie Neurobiologie Neurodegenerative Erkrankungen Virologie diseases gene neurobiology nucleic acid prion protein protein proteins tissue virology

Editors and affiliations

  • Bruce W. Chesebro
    • 1
  1. 1.Laboratory of Persistent Viral Diseases Rocky Mountain Laboratories National Institute of Allergy and Infectious DiseasesNational Institutes of HealthHamiltonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-76540-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-76542-1
  • Online ISBN 978-3-642-76540-7
  • Series Print ISSN 0070-217X
  • About this book