Autoimmune Thyroiditis

1. Front Matter

   Pages I-XXVII

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2. Immunogenetics

   1. Front Matter

      Pages 1-1

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   2. New Insights into Autoimmune Mechanisms and the Pathogenesis of Insulin-Dependent Diabetes Mellitus

      • W. A. Rudert, M. Trucco

      Pages 3-13

   3. Thyroid Antibodies and Thyroid Dysfunction in Patients with Type 1 Diabetes and Their First-Degree Relatives

      • F. Becker, H. Buschler, R. Bretzel, K. Federlin

      Pages 15-19

   4. Association of HLA Class I and Class II Genes and Adrenal Steroid 21-Hydroxylase Gene with Subacute (de Quervain’s) and Hashimoto’s Thyroiditis: Evidence for an Altered Negative Feedback in Hashimoto’s Thyroiditis

      • B. O. Boehm, E. Schifferdecker, B. Manfras, P. Kühnl, G. Holzberger, C. Rosak et al.

      Pages 21-28

   5. Strongest Relative Risk for Goitrous Hashimoto’s Thyroiditis Conferred by HLA-DQB1 Gene Variation

      • K. Badenhoop, G. Schwarz, P. G. Walfish, K. H. Usadel, G. F. Bottazzo

      Pages 29-39

   6. A Search for Linkage Between Phenylthiocarbamide Tasting, the Kell Blood Group Locus and Autoantibodies to Thyroglobulin and Thyroid Peroxidase

      • S. Lo, A. Stephenson, D. Phillips, S. M. McLachlan, G. Pyle, S. Moffitt et al.

      Pages 41-46

   7. Autoimmune Thyroiditis: Its Implications with Other Organ Systems

      • F. J. Seif

      Pages 47-54

   8. The Genetic Control of Thyroid Cell MHC Class II Antigen Expression

      • T. F. Davies, D. Neufeld

      Pages 55-62

3. Thyroid Peroxidase: Approaches Towards its Characterization

   1. Front Matter

      Pages 63-63

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   2. Clinical Applications of Thyroid Peroxidase Autoantibody Determination

      • S. Mariotti, P. Caturegli, P. Piccolo, G. Barbesino, A. Pinchera

      Pages 65-75

   3. Comparison Between Microsomal Antibodies by Immunofluorescence and Anti-TPO Antibodies in Healthy Individuals and Thyroid Autoimmune Diseases

      • U. Feldt-Rasmussen, M. Høier-Madsen, N. G. Rasmussen, L. Hegedüs, P. J. Hornnes, H. Perrild

      Pages 77-84

   4. Longitudinal and Cross-Sectional Studies on Anti-Thyroid Peroxidase Antibodies in Thyroid Disorders Compared to Conventional Anti-Microsomal Antibodies

      • K. Weber, H. Schatz

      Pages 85-89

   5. Comparison of New and Conventional Assay Techniques for Measuring Thyroid Microsomal Antibodies

      • R. Hoermann, B. Saller, A. Fateh-Moghadam, K. Mann

      Pages 91-97

   6. Further Clarification of the Significance of Thyroid Peroxidase Activity-Inhibiting Immunoglobulins in Autoimmune Thyroid Disease

      • Y. Okamoto, N. Hamada, J. Noh, K. Ito, H. Morii

      Pages 99-105

   7. Biochemical Dissection of the Reactivity of TPO Antibodies

      • B. Saller, R. Hörmann, K. Mann

      Pages 107-121

   8. T Cell Epitopes and Thyroid Peroxidase

      • N. Fukuma, S. McLachlan, D. I. W. Phillips, C. A. S. Pegg, B. Rapoport, B. Rees Smith

      Pages 123-130

   9. Thyroid Microsome/Thyroid Peroxidase Autoantigenic Epitopes Recognized by Autoantibodies Map to the Amino Terminal, the Central Core and the Carboxyl Terminal of the Molecule

      • J. P. Banga, P. S. Barnett, D. L. Ewins, M. J. Page, A. M. McGregor

      Pages 131-140

   10. Comparison of Circulating Thyroid Microsomal, Cytotoxic and Thyroid Peroxidase Antibodies

       • P. Wadeleux, J. Ruf, P. Carayon, R. Winand

       Pages 141-146

   11. Are TPO Antibodies and Cytotoxic Thyroid Antibodies Identical?

       • U. Bogner, H. Schleusener

       Pages 147-154

Current knowledge relevant to the understanding of thyroid autoimmunity is summarized in this book. Some of the world's leading scientists in this field review recent data from four subject areas: immunogenetics, thyroid peroxidase as an antigen, environmental factors, and cytokines. Much ongoing and as yet unpublished work is described, especially in the discussion included after each article. This information is of particular interest since the body of knowledge in these fields is growing very rapidly. The book is based on a workshop in which researchers from 13 countries took part. One major aim was to raise controversial points and to develop ideas for their potential solution. At the workshop it became apparent that a great deal of the information given in textbooks is outdated. This is an important update for researchers who are interested in the above topics and in understanding the etiology and pathogenesis of thyroid autoimmunity.

• Antigen
• Autoimmunerkrankungen
• Cytokine
• Diabetes
• Diabetes mellitus
• Interferon
• Interferontherapie
• Schilddrüse
• autoimmune disease

• Medizinische Klinik und Poliklinik, Abt. Innere Medizin, Universität Ulm, Ulm, Germany

  W. A. Scherbaum

• Abt. für Allgemeine Innere Medizin und Nephrologie, Medizinische Klinik und Poliklinik, Berlin 45, Germany

  U. Bogner

• Homburg/Saar, Germany

  B. Weinheimer

• Department of Immunology, The London Hospital Medical College, London, UK

  G. F. Bottazzo

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