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Acute Myelogenous Leukemia in Childhood

Implications of Therapy Studies for Future Risk-Adapted Treatment Strategies

  • Ursula Creutzig
  • Jörg Ritter
  • Günther Schellong

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Ursula Creutzig, Jörg Ritter, Günther Schellong
    Pages 1-5
  3. Ursula Creutzig, Jörg Ritter, Günther Schellong
    Pages 7-11
  4. Ursula Creutzig, Jörg Ritter, Günther Schellong
    Pages 13-16
  5. Ursula Creutzig, Jörg Ritter, Günther Schellong
    Pages 17-95
  6. Ursula Creutzig, Jörg Ritter, Günther Schellong
    Pages 97-137
  7. Ursula Creutzig, Jörg Ritter, Günther Schellong
    Pages 139-141
  8. Ursula Creutzig, Jörg Ritter, Günther Schellong
    Pages 143-154
  9. Ursula Creutzig, Jörg Ritter, Günther Schellong
    Pages 155-160
  10. Back Matter
    Pages 161-163

About this book

Introduction

The results of treatment for childhood acute myelogenous leukemia (AML) have improved considerably during the last ten years. This progress was demonstrated by the two consecutive multicenter studies, AML-BFM-78 and -83, in which almost identical extended multi drug regimes of che­ motherapy were administered for eight weeks and followed up by two years maintenance. The main difference in the second study was the addition of an eight-day intensive in­ duction course. Due to this new element, the relapse rate was reduced significantly. Another result of the BFM-83 study was the definition of two risk groups on the basis of standardized treatment, which has lead to a risk-adapted treatment strategy in the third ongoing trial, AML-BFM- 87. This improvement was only possible thanks to the coop­ eration of pediatricians, physicians, radiotherapists, statisti­ cians, and especially the staff at the hospitals and reference laboratories. Thus, we would like to thank everyone who has been involved in these studies and hope that they will be further encouraged to improve treatment strategies for AML in children. The coordination, enforcement, and analyses of the stud­ ies would not have been possible without the financial sup­ port of the Federal Ministry for Research and Technology of the FRG. We are grateful for the generous contributions supporting this book from Lederle and Farmitalia. Munster, April 1990 Ursula Creutzig Jorg Ritter Gunther Schellong Contents 1 Introduction . . . . .. . . . . . . . . . . . . . . .. . . . 1 .

Keywords

AML bei Kindern Risikogruppen Therapie blood cell chemotherapy childhood cytogenetics genetics leukemia

Editors and affiliations

  • Ursula Creutzig
    • 1
  • Jörg Ritter
  • Günther Schellong
  1. 1.Universitäts-KinderklinikMünsterGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-75351-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-52070-2
  • Online ISBN 978-3-642-75351-0
  • Buy this book on publisher's site