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Modern Trends in Human Leukemia VIII

New Results in Clinical and Biological Research Including Pediatric Oncology

  • Conference proceedings
  • © 1989

Overview

Editors:
  1. Rolf Neth

    1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Germany

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  2. Robert C. Gallo

    1. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, USA

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  3. Melvyn F. Greaves

    1. Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, London, UK

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  4. Gerhard Gaedicke

    1. Abteilung Pädiatrie II, Universitätskinderklinik und Poliklinik Ulm, Ulm, Germany
      Universität Ulm, Ulm, Germany

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  5. Sven Gohla

    1. Labor für Hautimmunologie, Bioverträglichkeit-Immunologie, Paul-Gerson-Unna-Forschungszentrum, Beiersdorf-AG, Germany

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  6. Klaus Mannweiler

    1. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Germany

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  7. Jörg Ritter

    1. Abteilung Hämatologie und Onkologie, Kinderklinik und Poliklinik der Westfälischen Wilhelms-Universität, Münster, Germany

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Part of the book series: Haematology and Blood Transfusion Hämatologie und Bluttransfusion (HAEMATOLOGY, volume 32)

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Table of contents (85 papers)

  1. Clinical Aspects

    1. Immunologic Subclassification of Acute Lymphoblastic Leukemia in Childhood and Prognosis (Modified BFM Protocol)

      • F. Zintl, R. Häfer
      Pages 109-112

    2. Constellations of Genetic Abnormalities Predict Clinical Outcome in Childhood Malignancies

      • A. T. Look
      Pages 113-120

    3. Leukemia Cytogenetics in Children: Results of the German Therapy Studies

      • J. Harbott, J. Ritterbach, F. Lampert
      Pages 121-126

    4. Cytostatic Influence of Thioproline on Peripheral Lymphocytes of Healthy Persons and Non-Hodgkin’s Lymphoma Patients

      • T. Rozmysłowicz
      Pages 127-130

    5. Diversity of Molecular Phenotypes in Acute Leukemias

      • S. Mizutani, K. Nakamura, M. Ozaki, C. Tamura, M. Sasaki, Y. Tsunematsu et al.
      Pages 131-133

    6. Treatment of Chronic Myelogenous Leukemia with Interferons: Hematologic, Cellular, and Genetic Investigations

      • B. Opalka, O. Kloke, U. Wandl, R. Becher, N. Niederle
      Pages 134-138

    7. α Interferon in Myelodysplasia

      • D. W. Galvani
      Pages 139-140

    8. Use of Investigational Drugs as Initial Therapy for Childhood Solid Tumors

      • W. H. Meyer, P. J. Houghton, M. E. Horowitz, E. Etcubanas, C. B. Pratt, F. A. Hayes et al.
      Pages 141-148

    9. Xenografts of Pediatric Solid Tumors: Predictive Intermediate Models?

      • P. J. Houghton, J. A. Houghton
      Pages 149-155

  2. Cell Biology

    1. Front Matter

      Pages 157-157
      Download chapter PDF

    2. Stromal-Hematopoietic Interrelationships: Maximov’s Ideas and Modern Models

      • A. Friedenstein
      Pages 159-167

    3. Bone Marrow Stromal Cells in Myelodysplastic Syndromes and Acute Nonlymphocytic Leukemia

      • E. Elstner, M. Wächter, R. Ihle
      Pages 168-171

    4. Growth and Development of Haemopoietic Cells: A Deterministic Process?

      • C. P. Daniel, I. L. O. Ponting, T. M. Dexter
      Pages 172-177

    5. Limited Proliferative Potential of Primitive Hematopoietic Stem Cells: Hematopoiesis by Clonal Succession

      • J. L. Chertkov, E. I. Deryugina, N. J. Drize, E. Yu. Sadovnikova
      Pages 178-182

    6. The Effect of Human and Rat Fetal Bone on Hematopoiesis In Vitro and In Vivo

      • B. V. Afanasyev, V. A. Shatrov, N. Balayan
      Pages 183-187

    7. Aberrant Expression of the Multi-CSF Gene in Hematopoietic Precursor and Stem Cell Lines Initiates Leukemogenic Progression

      • C. Laker, C. Stocking, N. Kluge, M. J. Franz, G. Beck-Engeser, E. Spooncer et al.
      Pages 188-196

    8. Infection of Multipotent IL-3-dependent Stem Cells With a Retroviral Vector Containing the IL-3 Gene Confers Density-dependent Growth Autonomy Without Blocking Differentiation

      • U. Just, E. Spooncer, M. Katsuno, I. Hampson, M. Dexter, J. F. DeLamarter et al.
      Pages 197-205

    9. Isolation of Revertants from a Factor-Independent Myeloid Cell Line

      • M. Kawai, T. Mori, C. Stocking, K. Notake
      Pages 206-207

    10. Comparison of Factors Which Induce Differentiation of the Murine Myeloid Leukaemic Cell Line M1

      • D. P. Gearing
      Pages 208-213

    11. Establishment of a Leukemic Cell Line MT-ALL With Multilineage Differentiation Potential

      • F. Griesinger, J. M. Greenberg, D. C. Arthur, A. C. Ochoa, C. Hurvitz, R. Brunning et al.
      Pages 214-219
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Keywords

About this book

You see things, and sa)' why? But I dream 1hings that never were, and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time, June 1st, 1909, Alexander Maximov communicated in a lecture, given in the Charite in Berlin, the fundamental knowledge, that there exists a lymphoid hemopoetic stem cell. Alexander Friedenstein explained that during the following years, Maximov also showed that the idea of interaction between hemopoetic cells and their stroma to be one of the most significant experiences. Monoclonal antibodies, recombinant DNA technics and the improvement of tissue culture models are the major developments to improve our possibilities to clarify growth and differentiation functions of hemopoetic cells. During the last two decades it was shown that soluble products, released from T cells, were not only involved in inducing B cells to produce specific immunoglobulin secretion after antigen stimulation. Furthermore, lymphokines together with other cytokines regulate the growth and differentiation of hemopoetic cells. As I have learned from Dick Gershon, our knowledge of the cellular basis for immunoregulation has come a long way since 450 B.C. Thucydides comments on the possible role of immune response in controlling the Black Death. Dick Gershon speculated that no scientific interest for these interesting observations was put forth at that time. Perhaps the problems, the Athenians were having with the Spartans, converted money from basis research into the military budget.

Editors and Affiliations

  • Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Germany

    Rolf Neth

  • Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, USA

    Robert C. Gallo

  • Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, London, UK

    Melvyn F. Greaves

  • Abteilung Pädiatrie II, Universitätskinderklinik und Poliklinik Ulm, Ulm, Germany

    Gerhard Gaedicke

  • Universität Ulm, Ulm, Germany

    Gerhard Gaedicke

  • Labor für Hautimmunologie, Bioverträglichkeit-Immunologie, Paul-Gerson-Unna-Forschungszentrum, Beiersdorf-AG, Germany

    Sven Gohla

  • Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Germany

    Klaus Mannweiler

  • Abteilung Hämatologie und Onkologie, Kinderklinik und Poliklinik der Westfälischen Wilhelms-Universität, Münster, Germany

    Jörg Ritter

Bibliographic Information

  • Book Title: Modern Trends in Human Leukemia VIII

  • Book Subtitle: New Results in Clinical and Biological Research Including Pediatric Oncology

  • Editors: Rolf Neth, Robert C. Gallo, Melvyn F. Greaves, Gerhard Gaedicke, Sven Gohla, Klaus Mannweiler, Jörg Ritter

  • Series Title: Haematology and Blood Transfusion Hämatologie und Bluttransfusion

  • DOI: https://doi.org/10.1007/978-3-642-74621-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1989

  • Softcover ISBN: 978-3-540-50967-7Published: 22 December 1989

  • eBook ISBN: 978-3-642-74621-5Published: 06 December 2012

  • Series ISSN: 0440-0607

  • Edition Number: 1

  • Number of Pages: LVII, 533

  • Number of Illustrations: 85 b/w illustrations

  • Topics: Hematology, Immunology, Pediatrics, Oncology, Allergology, Virology

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