Salt and Hypertension

Dietary Minerals, Volume Homeostasis and Cardiovascular Regulation

  • R. Rettig
  • D. Ganten
  • F. C. Luft

Table of contents

  1. Front Matter
    Pages I-XIX
  2. Electrolyte and Volume Homeostasis

    1. Front Matter
      Pages 1-1
    2. D. Denton, M. McKinley, E. Tarjan, R. Weisinger
      Pages 3-11
    3. E. Ritz, J. Mann, M. Schmid
      Pages 12-22
  3. Cellular Mechanisms

    1. Front Matter
      Pages 33-33
    2. D. Ely, B. Folkow, N. F. Paradise
      Pages 66-82
    3. S. Oparil, Y.-F. Chen, R.-H. Yang, H. Jin, Q. C. Meng, E. J. Cragoe et al.
      Pages 83-96
    4. P. J. Mulrow, E. Kusano, K. Baba, Y. Doi, D. Shier, R. Franco-Saenz
      Pages 107-118
  4. Genetic Determinants of Salt Sensitivity

    1. Front Matter
      Pages 119-119
    2. M. H. Weinberger, F. C. Luft, J. Z. Miller, C. E. Grim, N. S. Fineberg, J. C. Christian
      Pages 121-127
    3. R. R. Williams, S. C. Hunt, S. J. Hasstedt, P. N. Hopkins, L. L. Wu, T. D. Berry et al.
      Pages 139-155
  5. Pathophysiological Significance of Different Types of Minerals

    1. Front Matter
      Pages 157-157
    2. T. B. Drüeke, C. Roullet, P. A. Lucas
      Pages 159-168
    3. J. R. Sowers, P. Zemel, P. Standley, J. Kraniak, M. B. Zemel
      Pages 169-175
    4. D. A. McCarron, E. W. Young, R. D. Bukoski, C. D. Morris
      Pages 176-189
    5. T. A. Kotchen, S. Reddy, C. Genain, N. Blehschmidt
      Pages 200-210
    6. T. W. Kurtz, R. C. Morris Jr.
      Pages 211-217
    7. J. Girndt
      Pages 235-241
    8. H. Meyer-Lehnert, H. J. Kramer
      Pages 249-257
    9. R. de Châtel, M. Tóth, A. Tislér, I. Barna, M. Herendi, M.-A. Vossbein
      Pages 258-271
  6. Epidemiology of Salt Consumption and Intervention Trials

    1. Front Matter
      Pages 273-273
    2. J. M. Kotchen, P. Taylor, M. McFadden, B. Ngai, G. P. Guthrie Jr., T. A. Kotchen
      Pages 275-282
    3. D. E. Grobbee, A. A. A. Bak
      Pages 283-292
    4. H. Heine, L. Heinemann, W. Barth, H. D. Faulhaber
      Pages 293-299
    5. Y. Yamori
      Pages 319-328
    6. F. C. Luft, W. R. Harlan, L. C. Harlan
      Pages 329-338
  7. Back Matter
    Pages 345-366

About these proceedings


Controversy regarding the wisdom of a high salt intake has been with us for 5000 years. In the Nei Ching, the oldest of the extant medical writings, the Yellow Emperor observed, "Hence, if too much salt is in the food, the pulse hardens, tears make their appearance, and the complexion changes". At about the same period in history, Job asked the question, "Can that which is unsavory be eaten without salt?" It is not apparent whether or not the Almighty provided a clear answer. The connection between dietary salt intake and hypertension was appreciated following the observations of AMBARD, BEAUJARD, VOLLHARD, ALLEN, and others. However, DAHL emphasized this relationship, as demonstrated by his epidemiological observations, his studies in human subjects, and his development of a genetically mediated form of salt-sensitive hypertension in rats. DAHL and his followers argued that hypertension was a disease of acculturation, or even of self-abuse. Undaunted by skeptics such as PICKERING, they suggested that if Western man would merely curtail his intake of the granular condiment, hypertension would not develop and blood pressure would not increase with age. Bucolic native societies were given as examples where such cardiovascular bliss was readily attained.


age arterial pressure artery blood blood pressure cardiovascular development epidemiological hypertension kidney stroke

Editors and affiliations

  • R. Rettig
    • 1
  • D. Ganten
    • 1
  • F. C. Luft
    • 2
  1. 1.German Institute for High Blood Pressure Research and Department of PharmacologyUniversity of HeidelbergHeidelbergWest Germany
  2. 2.Indiana Univ. School of MedicineIndianapolisUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1989
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-73919-4
  • Online ISBN 978-3-642-73917-0
  • Buy this book on publisher's site