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Methods in Protein Sequence Analysis

Proceedings of the 7th International Conference, Berlin, July 3–8, 1988

  • Conference proceedings
  • © 1989

Overview

Editors:
  1. Brigitte Wittmann-Liebold

    1. Abteilung Wittmann, Max-Planck-Institut für Molekulare Genetik, Dahlem, Germany

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Table of contents (71 papers)

  1. Front Matter

    Pages I-XXXV
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  2. A Critical Evaluation of Sensitive Amino Acid Analysis

    1. Front Matter

      Pages 1-1
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    2. Detection Limits in Amino Acid Analysis: An Overview

      • P. E. Hare
      Pages 2-9

    3. Amino Acid Analysis at High Sensitivity: A Critical Review of the Communications

      • Graham J. Hughes, Séverine Frutiger
      Pages 10-13

    4. A Comparison of 9-Fluorenylmethylchloroformate (FMOC-Cl) Amino Acid Analysis with Ninhydrin and Phenylthiocarbamyl (PTC) Chemistries

      • Alan J. Smith, Jack M. Presley, William McIntire
      Pages 14-18

    5. Localization of Endogenous Phosphoserine Residues in the Primary Structure of Proteins

      • H. E. Meyer, C. C. Kuhn, G. F. Meyer, K. Swiderek, C. Weber, E. Hoffmann-Posorske et al.
      Pages 19-22

    6. Quantitative N-terminal Analysis of Polypeptides

      • Jui-Yoa Chang
      Pages 23-32

  3. New Approaches for the Chemistry of the Edman Degradation

    1. Front Matter

      Pages 33-33
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    2. Study on New Edman-type Reagents

      • Jin Shan-Wei, Xu Shan-Zhen, Zhang Xiu-Lan, Tang Tian-Bao
      Pages 34-41

    3. Protein Microsequence Analysis with Dansylamino-PITC

      • Hisashi Hirano, Brigitte Wittmann-Liebold
      Pages 42-51

    4. Manual Gas Phase Isothiocyanate Degradation

      • Wolf F. Brandt, Gerhard Frank
      Pages 52-59

  4. New Instrumentation in Sequence Analysis and Synthesis of Biopolymers

    1. Front Matter

      Pages 60-60
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    2. A Second Generation Solid-phase Protein Sequencer: The Prosequencer™

      • Richard A. Laursen, James D. Dixon, Song-Ping Liang, Duc M. Nguyen, Terri Kelcourse, Lawrence Udell et al.
      Pages 61-68

    3. Development of Membrane Supports for the Solid-phase Sequence Analysis of Proteins and Peptides

      • James M. Coull, James D. Dixon, Richard A. Laursen, Hubert Köster, Darryl Pappin
      Pages 69-78

    4. Accelerated High Sensitivity Sequence Analysis of Proteins and Peptides Immobilized on Chemically-modified Glass Fiber Discs

      • Ruedi H. Aebersold, Heinz Nika, Gary D. Pipes, Richard E. H. Wettenhall, Stephen M. Clark, Leroy E. Hood et al.
      Pages 79-97

    5. A New Modular Sequencer

      • Stefan Fischer, Frank Reimann, Brigitte Wittmann-Liebold
      Pages 98-107

    6. An Improved Injection System for On-line High Sensitivity Phenylthiohydantoin Amino Acid Analysis

      • Geoffrey S. Begg, Richard J. Simpson
      Pages 108-111

    7. Design and Performance Features of a Simplified Protein Sequencer with an On-Board Isocratic HPLC System

      • R. J. Mattaliano, K. A. Yamada, J. K. Hughes, P.-M. Yuan
      Pages 112-115

    8. New Aspects in Isocratic HPLC Separation of Phenylthiohydantoin Amino Acids Through the Application of Ionic Detergents

      • Gerhard Frank
      Pages 116-121

    9. A Procedure for the Manual Precyclization of Fiber Glass Filters used in the ABI 470A Protein Sequencer

      • Billy Touchstone, Zi-Wei Gu, Chao-Yuh Yang
      Pages 122-127
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Keywords

About this book

"Methods in Protein Sequence Analysis - 1988" - contains selected contributions on modern protein- analytical techniques as presented by speakers at the Seventh International Conference on "Methods in Protein Sequence Analysis", held from July 3rd to July 8th, 1988 in Berlin. The book contains information on new methodologies for sensitive amino acid analysis, N- and C-terminal sequence analysis, and protein and peptide purification. In addition recent mass spectrometric approaches are described, as an alter­ native technique to the common stepwise degradative sequence analysis of polypeptides by the Edman method. The book presents new possibilities in the design of sequencers and sophisticated equipment for the structural analysis of peptides and proteins. It describes practical approaches for the investigation of protein domains and protein complexes, and contains review chapters on the crystallization of cell organelles as well as on recent theoretical aspects of protein folding mechanisms. The nature of protein folding is not yet understood, but further advances in this area would greatly enhance our present knowledge of protein structure and function. Further, the book gives examples of the application of gene technology to protein characterization and to the design of new proteins. This enables new studies on the structure and function of proteins to be made, and opens up efficient approaches to the design of drugs.

Editors and Affiliations

  • Abteilung Wittmann, Max-Planck-Institut für Molekulare Genetik, Dahlem, Germany

    Brigitte Wittmann-Liebold

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