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Cellular and Molecular Alterations in the Failing Human Heart

  • G. Hasenfuss
  • Ch. Holubarsch
  • H. Just
  • N. R. Alpert

Table of contents

  1. Front Matter
    Pages I-XII
  2. Sarcolemma and phosphodiesterases

    1. Front Matter
      Pages XIII-XIII
    2. Otto-Erich Brodde, A. Broede, A. Daul, K. Kunde, M. C. Michel
      Pages 1-14
    3. T. Eschenhagen, U. Mende, M. Nose, W. Schmitz, H. Scholz, J. Schulte am Esch et al.
      Pages 51-64
    4. W. Schmitz, T. Eschenhagen, U. Mende, F. U. Müller, J. Neumann, H. Scholz
      Pages 65-71
    5. Paul D. Allen, T. A. Schmidt, J. D. Marsh, K. Kjeldsen
      Pages 87-94
  3. Excitation-contraction coupling and contractile proteins

    1. Front Matter
      Pages N3-N3
    2. G. Hasenfuss, L. A. Mulieri, B. J. Leavitt, P. D. Allen, C. Holubarsch, H. Just et al.
      Pages 107-116
    3. Page A. W. Anderson, N. N. Malouf, A. E. Oakeley, E. D. Pagani, P. D. Allen
      Pages 117-127
    4. H.-P. Vosberg, U. Horstmann-Herold, A. Wettstein
      Pages 161-173
    5. B. Chevalier, D. Charlemagne, F. Callens-el Amrani, F. Carre, J. M. Moalic, C. Delcayre et al.
      Pages 187-197
    6. B. Pieske, G. Hasenfuss, Ch. Holubarsch, R. Schwinger, M. Böhm, H. Just
      Pages 213-221
    7. E. M. Blanchard, B. J. Leavitt, L. A. Mulieri, N. R. Alpert
      Pages 245-253
    8. K. Schwartz, L. Carrier, A.-M. Lompré, J.-J. Mercadier, K. R. Boheler
      Pages 285-290
  4. Extracellular matrix

    1. Front Matter
      Pages N5-N5
    2. Jutta Schaper, B. Speiser
      Pages 303-309
  5. Mitochondrial function

  6. Achievements of the Symposium

    1. Front Matter
      Pages N9-N9
    2. Ch. Holubarsch, G. Hasenfuss
      Pages 331-342
  7. Back Matter
    Pages 343-346

About these proceedings

Introduction

The myocardium in heart failure: Cellular and subcellular alterations in the failing human myocardium. H. Just Medizinische Universitatsklinik Freiburg i. Br., Innere Medizin III - Kardiologie, FRG The syndrome of heart failure continues to be a major challenge to clinicians and scientists. Incidence and mortality of the disease are high, the patient is disabled, and is permanently threatened by the high morbidity and mortality. The clinician faces a syndrome of complex pathophysiology. Multiple causes or underlying disorders of the heart have to be differentiated from heart failure itself, which often results in exceedingly difficult diagnoses. Likewise, prognostication meets with difficulties due to problems in separating influences of the underlying disease and the heart failure syndrome itself. In chronic refractory failure annual mortality may exceed 50%. If aortic stenosis or ischemic cardiomyopathy with main­ stem lesions are present, this percentage may be even higher. The situation becomes particularly threatening to the patient when the reduction in cardiac performance goes along with complex ventricular arrhythmias. Therapy has remained difficult and of limited effectiveness. Major progress was achieved with the introduction of diuretic substances. Of similar importance was the introduction of va so dilating drugs into the treatment of heart failure. The principle of vasodilation has greatly improved our understanding of the disease, and has brought about a major improvement of symptoms, increase of exercise capacity, and reduc­ tion of mortality. This is especially true for the introduction of the angiotensin converting enzyme inhibitors.

Keywords

cardiovascular cardiovascular function heart heart failure heart muscle metabolism pathophysiology physiology protein proteins

Editors and affiliations

  • G. Hasenfuss
    • 1
  • Ch. Holubarsch
    • 1
  • H. Just
    • 1
  • N. R. Alpert
    • 2
  1. 1.Innere Medizin III, KardiologieAlbert-Ludwigs-Universität Medizinische UniversitätsklinikFreiburgGermany
  2. 2.Department of Physiology and BiophysicsUniversity of VermontBurlingtonUSA

Bibliographic information