Differentiation of B Lymphocytes

  • Christopher J. Paige
  • Roland H. Gisler
Conference proceedings

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 135)

Table of contents

  1. Front Matter
    Pages I-IX
  2. P. W. Kincade, P. L. Witte, K. S. Landreth
    Pages 1-21
  3. B. A. Malynn, J. E. Berman, G. D. Yancopoulos, C. A. Bona, F. W. Alt
    Pages 75-94
  4. P. D. Burrows, H. Kubagawa
    Pages 125-138
  5. N. Sakaguchi, C. N. Berger, F. Melchers
    Pages 139-148
  6. Back Matter
    Pages 149-150

About these proceedings

Introduction

Rapid progress continues to be made in understanding the molecular and cellular events that comprise B-Iymphocyte differentiation. This is due in part to the high level of inter­ est shown by many investigators from diverse disciplines, who find this subject suitable for addressing some of the fundamental issues of immunobiology. B-cell developmen­ tal models are being extensively used to investigate cell-cell interactions, molecular mediators of differentiation and proliferation, differential onset of gene programs, and gene rearrangement and expression, as well as the generation of the immune response itself. Not surprisingly, increased understanding of B-cell differentiation sometimes results from the application of new techniques that permit greater insight into the cells comprising the system and the genetic mechanisms by which these cells express their differentiative potential. However, experimental strategies based upon the novel application of established technologies have also led to the clarification of many issues, as well as to the discov­ ery of previously unrecognized problems. One problem, well recognized by those active in the field, is how to keep up with significant developments as they appear. The purpose of this book, part of a series devoted to analysing current issues in biology, is to help overcome this problem. No attempt at comprehensive cov­ erage of all of the issues has been made. Rather, a more thorough analysis of a few topics is presented.

Keywords

gene immune response immunobiology lymphocytes proliferation

Editors and affiliations

  • Christopher J. Paige
    • 1
  • Roland H. Gisler
    • 1
  1. 1.Basel Institute for ImmunologyBaselSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71851-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71853-3
  • Online ISBN 978-3-642-71851-9
  • Series Print ISSN 0070-217X
  • About this book