Peptides as Immunogens

  • Hilary Koprowski
  • Fritz Melchers
Conference proceedings

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 130)

About these proceedings

Introduction

The humoral response of the immune system to a foreign antigen usually requires the recognition of two antigenic determinants. The one, called the carrier, is recognized by T-Iymphocytes, the other, called the hapten, by B-Iympho­ cytes. As a consequence, T - and B-Iymphocytes proliferate, B-Iymphocytes produce hapten-specific antibodies, and the system develops memory to the antigens. It was long thought that antigens would form a bridge to mediate the cooperation of T - and B-Iymphocytes. However, it now appears that antigens are broken down to fragments which then act as carrier determinants for T -lymphocytes. The cells which originally process antigen are called an­ tigen-presenting cells. They have phagocytic properties. They can take up and degrade antigens, in the case of pro­ teins to peptides. The peptides of protein antigens reappear on the surface of the antigen-presenting cells, where they must become associated with membrane proteins encoded by genes of the major histocompatibility complex (MHC) in order to be recognized by T-Iymphocytes. To activate helper T-Iym­ phocytes which cooperate in antibody responses, MHC class II molecules have to be expressed on the surface of the antigen-presenting cells. Once T -lymphocytes have be­ come activated, they are ready to cooperate with B cells.

Keywords

antibody antigen histocompatibility immune system lymphocytes protein proteins

Editors and affiliations

  • Hilary Koprowski
    • 1
  • Fritz Melchers
    • 2
  1. 1.The Wistar InstitutePhiladelphiaUSA
  2. 2.Institute for ImmunologyBaselSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71440-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 1986
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71442-9
  • Online ISBN 978-3-642-71440-5
  • Series Print ISSN 0070-217X
  • About this book