Drugs and Aging

  • Dieter Platt

Table of contents

  1. Front Matter
    Pages I-XI
  2. A. Macieira-Coelho, B. Azzarone
    Pages 35-44
  3. C. F. A. Van Bezooijen, G. J. M. J. Horbach, C. F. Hollander
    Pages 45-55
  4. A. Ruiz-Torres, R. Velasco
    Pages 140-143
  5. W. Möhrke, E. Mutschler, W. Mühlberg, D. Platt
    Pages 144-151
  6. W. Mühlberg, D. Platt, E. Mutschler, W. Möhrke
    Pages 152-163
  7. H. Spahn, W. Mühlberg, E. Mutschler, D. Platt
    Pages 164-170
  8. G. Hofecker, M. Skalicky, H. Niedermüller, A. Kment
    Pages 171-182
  9. G. Menke, P. Pfister, A. H. Staib, B. G. Woodcock, I. Rietbrock
    Pages 183-190
  10. M. R. P. Hall
    Pages 191-196

About these proceedings

Introduction

Experimental gerontological research is necessary to obtain optimal information and thus ensure proper drug therapy for the elderly. Most older persons acquire multiple diseases, first of all chronic diseases. They involve complex problems of a physical, social, and psychological nature. The multimorbidity of the elderly raises many questions in drug therapy. By contrast with our extensive knowledge of pharmacokinetics and pharmacodynamics in younger age groups, few facts are available in respect of the elderly. A variety of factors may influence drug therapy. Physiological and pathological age-related changes of molecules, cells, organs, and the total organism may interact to enhance or inhibit drug therapy in higher age groups. It is well known that elderly patients are overmedicated and therefore the incidence of adverse drug reactions increases with age. Elderly patients with multimorbidity often have a diminished body clearance of drugs; age-related changes of the kidney seems to be one of the most important factors in this regard. Far less important than the elimination of drugs through the kidney is their excretion in the bile. So far results have disclosed that oxidative steps in drug clearance are more likely to be disturbed than phase II reactions. Furthermore; changes in distribution volume and age-related alterations in receptor sensitivity also influence the clearance of drugs in the elderly.

Keywords

Drugs drug kidney kinetics pharmacodynamics pharmacokinetics research

Editors and affiliations

  • Dieter Platt
    • 1
    • 2
  1. 1.Universität Erlangen-NürnbergNürnbergGermany
  2. 2.2. Medizinischen Klinik Klinikum NürnbergNürnbergGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-70788-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1986
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-70790-2
  • Online ISBN 978-3-642-70788-9
  • About this book