Skin Models

1. In Vivo Models

   1. Thermography as a Model for Cutaneous Vascular Responses

      • G. Stüttgen

      Pages 155-164

   2. The Long-Haired Syrian Hamster: An Animal Model for Androgen Induced Hair Growth

      • N. Orentreich, J. R. Matias

      Pages 165-171

   3. Biochemical Markers in the Mouse Tail Model of Psoriasis

      • P. T. Bladon, N. F. Cooper, E. J. Wood, W. J. Cunliffe

      Pages 172-182

   4. Corneocyte Exfoliative Cytology: A Model to Study Normal and Diseased Stratum Corneum

      • E. Hölzle, G. Plewig, A. Ledolter

      Pages 183-193

   5. Modulation of EGF Receptors during Epidermal Hyperplasia

      • D. A. Basketter

      Pages 194-198

   6. Comparative Study of the Keratin Polypeptide Profiles in Human and in Pig Hyperkeratotic Scabies

      • D. Van Neste, M. J. Staquet, G. P. Martineau, J. P. Ortonne

      Pages 199-204

2. In Vitro Models

   1. Front Matter

      Pages 205-205

      PDF

   2. Role of Extracellular Matrix in Skin Morphogenesis, Analysed by Dermal Cell Cultures

      • P. Sengel, M. Kieny

      Pages 206-217

   3. The Development of Epidermis In Vitro. Electronmicroscopic and Autoradiographic Studies in the Limb Bud Culture

      • U. Schultz-Ehrenburg

      Pages 218-236

   4. In Vitro Perfusion of Human Skin

      • H. Hiernickel

      Pages 237-244

   5. The Use of Human Scalp and Abdominal Skin as In Vitro Models for Percutaneous Absorption

      • S. L. Bennett, B. W. Barry

      Pages 245-256

   6. An In Vitro Human Skin Model for Assaying Topical Drugs against Dermatophytic Fungi

      • A. M. Kligman, K. J. McGinley, A. Foglia

      Pages 257-263

   7. In Vitro Models for Cutaneous Phototoxicity

      • B. E. Johnson, E. M. Walker, A. M. Hetherington

      Pages 264-281

   8. HET (Hen’s Egg Test) in Toxicological Research

      • N. P. Luepke

      Pages 282-291

   9. Use of Uninvolved Psoriatic Epidermis as an In Vitro Model for Testing the Anti-Phospholipase Activity of Glucocorticoids

      • A. Ilchyshyn, E. Ilderton, J. Kingsbury, J. F. B. Norris, R. Summerly, H. J. Yardley

      Pages 292-296

   10. Skin Fibroblast Monolayers: A Suitable Case for Treatment?

       • G. C. Priestley

       Pages 297-304

   11. Model for Biochemical Studies on the Mechanisms Underlying the Regulation of Cholesterol Synthesis

       • M. Ponec, J. Kempenaar, L. Havekes, B. J. Vermeer

       Pages 305-314

   12. A Model for Morphological Studies on Ligand-Receptor Complexes

       • B. J. Vermeer, A. M. Mommaas-Kienhuis, M. C. Wijsman, J. J. Emeis, M. Ponec

       Pages 315-326

   13. Use of In Vivo and In Vitro Test Systems as Predictors of the Cutaneous Irritancy of Synthetic Detergents (Syndets)

       • P. J. Dykes, D. L. Williams, L. A. Jenner, R. Marks

       Pages 327-332

   14. Lectin Induction of Pemphigus and Pemphigoid-Like Bullae in Organ Cultured Human Skin

       • M. Fitzmaurice, S. D. Deodhar

       Pages 333-346

In the last fifty years dramatic progress has been made in the under­ standing of skin and skin diseases. Although we are still someway off understanding the ultimate causes of such disorders as psoriasis, atopic dermatitis and the congenital disorder of keratinization, we now have considerable information on the physiological disturbances in various diseases. This has permitted and encouraged a rational approach to treatment. The successful use of antimitotic agents, immunomodulators and retinoids may be cited as examples. A major reason for this im­ provement may be the fact that researchers accept models for the in­ vestigation of skin diseases. Increasing numbers of them have become available in the past years. So many have been described that it is doubtful whether anyone researcher is aware of all the other models described - even in his own field of interest. This book is a challenge for those involved in the study of skin and its disorders to use the sundry models of skin that have proven helpful. It would be impossible for this work to be all-embracing but it is hoped that the choice of models offered in this publication will be stimulating and helpful in the solution of knotty skin questions. April,1986 Ronald Marks, Cardiff Gerd Plewig, DUsseldorf Table of Contents In Vivo Models Human Model for Acne . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 L. C Brummitt, W. J. Cunliffe, G. Gowland Models to Study Follicular Diseases l3 G. Plewig Models for Wound Healing. . . . . . . . . . . . . . . . . . . . . . . . . 24 R. Marks, D. Williams, A. D.

• Dermatitis
• Haut
• Skin
• psoriasis
• skin disease

• Department of Medicine, University of Wales College of Medicine, Cardiff, UK

  Ronald Marks

• Universitäts-Hautklinik Düsseldorf, Düsseldorf 1, Germany

  Gerd Plewig

Policies and ethics