Current Topics in Microbiology and Immunology

  • M. Cooper
  • P. H. Hofschneider
  • H. Koprowski
  • F. Melchers
  • R. Rott
  • H. G. Schweiger
  • P. K. Vogt
  • R. Zinkernagel

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 102)

Table of contents

About this book

Introduction

Binding of various ligands (hormones, neurotransmitters, immunological stimuli) to membrane receptors induces the following changes: 1. Receptor redistribution (clustering, "capping") 2. Conformational changes that can be detected by fluorescent probes 3. Alteration in membrane fluidity (spin label and fluorescence polarization probes) 4. Changes in fluxes of ions and metabolites 5. Increased phospholipid turnover (especially of phosphatidyl inositol) 6. Activation of membrane-bound enzymes (adenyl cyclase, ATPase, transmethylases). Some of the early changes resulting from or associated with the binding (adsorption) of virions to the host cell membrane are of the same type. Adsorption of animal viruses to cells is the ftrst step in a chain of events resulting in the production of progeny virus on the one hand and in damage to cells and tissues on the other. In the classical studies of viral infection, cells are adsorbed with virus, usually for 60 min, and the changes induced by the virus in the host cell are recorded thereafter. In the past decade, more and more studies have been aimed at the events occurring in these ftrst 60 min of the so-called adsorption period. These studies deal with the nature of adsorption, e. g. , the ligand-receptor type of interaction between the virus and the cell membrane. Many receptors for viruses were identifted and so were the viral proteins which take part in adsorption.

Keywords

ATPase cell immunology infection microbiology protein proteins virus

Editors and affiliations

  • M. Cooper
    • 1
  • P. H. Hofschneider
    • 2
  • H. Koprowski
    • 3
  • F. Melchers
    • 4
  • R. Rott
    • 5
  • H. G. Schweiger
    • 6
  • P. K. Vogt
    • 7
  • R. Zinkernagel
    • 8
  1. 1.BirminghamUSA
  2. 2.MartinsriedGermany
  3. 3.PhiladelphiaUSA
  4. 4.BaselSwitzerland
  5. 5.GießenGermany
  6. 6.Ladenburg, HeidelbergGermany
  7. 7.Los AngelesUSA
  8. 8.ZürichSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-68906-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1983
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68908-6
  • Online ISBN 978-3-642-68906-2
  • Series Print ISSN 0070-217X
  • About this book