Mediators and Drugs in Gastrointestinal Motility II

Endogenous and Exogenous Agents

  • Giulio Bertaccini

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 59 / 2)

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. G. Bertaccini
    Pages 11-83
  3. G. Bertaccini
    Pages 85-135
  4. G. Bertaccini
    Pages 137-159
  5. G. Bertaccini
    Pages 161-174
  6. G. Bertaccini
    Pages 201-218
  7. A. Bennett, G. J. Sanger
    Pages 219-248
  8. M. A. Eastwood, A. N. Smith
    Pages 323-346
  9. A. Torsoli, E. Corazziari
    Pages 347-376
  10. Back Matter
    Pages 377-388

About this book


This volume places more emphasis on endogenous mediators of gut motility than on drugs used to treat patients with deranged motility. In this respect it resembles most other books on gastroenterology, for while only a relatively small number of drugs are really useful for a rational therapy, a tremendous amount of data is available on neural and hormonal factors regulating the motility of the alimentary canal. Moreover, it must be considered that some of the drugs which can routinely be employed to modify deranged motility of the digestive system are represented by pure or slightly modified endogenous compounds (e. g. , cholecystokinin, its C­ terminal octapeptide and caerulein), and it is easy to foresee that their number is destined to increase in the near future. Other drugs are simply antagonists of physiological substances acting on specific receptors (e. g. , histamine H -blockers 2 and opioid compounds). The real explosion of research in this field and the extreme specialization often connected with the use of very sophisticated techniques and methodologies would probably have required a larger number of experts to cover some very specific fields from both an anatomical (lower esophageal sphincter, stomach, pylorus, small and large intestine) and a biochemical (hormones, candidate hormones, locally active substances, neurotransmitters etc. ) point of view.


Drugs Motility agents neurotransmitter opioid research

Editors and affiliations

  • Giulio Bertaccini
    • 1
  1. 1.School of MedicineUniversity of ParmaParmaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1982
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68476-0
  • Online ISBN 978-3-642-68474-6
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site