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Initiation Signals in Viral Gene Expression

  • Aaron J. Shatkin

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 93)

About this book

Introduction

Elucidating Mechanisms of Eukaryotic Genetic Expression by Studying Animal Viruses AARON 1. SHATIGN* Eukaryotic genetic expression is carefully regulated. Normal cell growth and division, tis­ sue differentiation, and organism development all depend on a strictly ordered progres­ sion of specific events. Perturbation of the control of these processes, for example by ex­ posure to harmful chemicals or infection with viruses leads to aberrant forms of meta­ bolism, often resulting in malignancies and cell death. One of the most challenging problems in biology is to derme at the molecular level the mechanisms that govern gene function in higher organisms, including ultimately man. This goal serves to unify the diverse efforts of many investigators, whether studying the precise patterns of embryo­ genesis, the loss of control that occurs during neoplastic growth or the redirection of biosynthetic pathways in virus-infected cells. Recently there has been remarkable and exciting progress toward understanding the molecular biology of eukaryotic expression. Much of this rapidly increasing new infor­ mation has come from studies of animal virus systems. Just as investigations of the relatively simple, rapidly assayed, and easily manipulated bacteriophages lead to basic discoveries about prokaryotic cells, analyses of animal viruses and their interactions with host cells have provided fundamental information about how eukaryotic nucleic acids are organized for regulated replication, transcription, and translation. For example, the small genome of SV , like cellular DNA in chromatin, is associated with histones to 40 form nucleosomal arrays (Griffin 1975).

Keywords

DNA Signals cell gene gene expression genes infection molecular biology transcription translation virus

Editors and affiliations

  • Aaron J. Shatkin
    • 1
  1. 1.Laboratory of Molecular VirologyRoche Institute of Molecular BiologyNutleyUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-68123-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1981
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68125-7
  • Online ISBN 978-3-642-68123-3
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site