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Pathology of the Gastro-Intestinal Tract

  • B. C. Morson

Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 63)

Table of contents

  1. Front Matter
    Pages i-vi
  2. A A. Johansen
    Pages 1-47
  3. H. Thompson
    Pages 49-75
  4. H. T. Enterline
    Pages 95-141
  5. M. I. Filipe, A. C. Branfoot
    Pages 143-178
  6. J. M. Skinner, R. Whitehead
    Pages 259-288
  7. Back Matter
    Pages 343-356

About these proceedings

Introduction

Immunology, in all its facets of immunochemistry, humoral immunity, cellular immunity, immunodiagnosis, and immunotherapy, is currently the most rapidly advancing discipline of clinical and experimental oncology. But as in most developing subjects, it is continually beset with problems of methodology and nomenclature, both of which are often intertwined. Indicative of this problem are our circular definitions of antigen and antibody. Another fre­ quent problem is the use of the words "specific" and "associated" when characterizing re­ actions to tumors or the antigenic properties of neoplasms. When applied to cancer, these terms are obviously very dependent upon the methods used to demonstrate these qualities. Indeed, the very diverse nature and multitude of types of cancer preclude our making gen­ eralizations or categorical statements regarding tumor "specificity. " Similar problems arise when one considers that many antigens found in malignant tumors share certain properties with embryonic or fetal tissues. First, these observations emphasize a lack of true tumor specificity, for which reason the category of oncofetal antigens has been established. Second, whether or not such antigens are truly oncofetal depends upon the method of detection used, and it has been found that here too specificity decreases as the antigen assay increases in sen­ sitivity. Thus, whether substances can be truly oncofetal in nature still remains a matter of debate, and such terms must therefore be used in an operational sense.

Keywords

cancer chemistry diagnosis embryo immunology neoplasm nomenclature oncology pathology therapy tissue tumor

Editors and affiliations

  • B. C. Morson
    • 1
  1. 1.Pathology DepartmentSt. Mark’s HospitalLondonGreat Britain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-66481-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1976
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-66483-0
  • Online ISBN 978-3-642-66481-6
  • Series Print ISSN 0070-2188
  • Buy this book on publisher's site