Molecular and Cellular Mechanisms in Disease

1: Bioenergetics · Cell Specificity · Inborn Errors of Metabolism · Malnutrition · Calcium and Phosphorus Iron and Bile Pigments · Coagulopathies · Hormones Body Fluids and Electrolytes

  • Julien L. Van Lancker

Table of contents

  1. Front Matter
    Pages I-XV
  2. Julien L. Van Lancker
    Pages 1-70
  3. Julien L. Van Lancker
    Pages 71-141
  4. Julien L. Van Lancker
    Pages 143-244
  5. Julien L. Van Lancker
    Pages 245-330
  6. Julien L. Van Lancker
    Pages 331-359
  7. Julien L. Van Lancker
    Pages 361-395
  8. Julien L. Van Lancker
    Pages 397-422
  9. Julien L. Van Lancker
    Pages 423-536
  10. Julien L. Van Lancker
    Pages 537-603
  11. Back Matter
    Pages 605-632

About this book

Introduction

In spite of ingenious experiments, imaginative theories, and unshakable faith in supreme forces, there is no way to know how life began. What is certain is that in the course of the development of the universe existing sources of energy fused to generate atoms, and atoms mingled to become small molecules. At some point by chance or design-according to one's belief, but no one's evidence-small molecules such as hydrogen, oxygen, carbon dioxide, water, and ammonia reacted to yield larger molecules with the property most essential to life: self-replication. Such molecules had to achieve a proper balance between the stability needed for their survival in the environment and the mutability for the generation of many forms of life. How amino acids were created or how DNA, RNA, and proteins developed remains a mystery. But we know that a simple core of nucleic acid embedded in a protein coat made the simplest unit of life (except for viroids). Whether viruses are a primitive or degenerated form of life is not known. Once proteins appeared, their great structural plasticity allowed them to react with other elements such as sulfur, iron, copper, and zinc. After an incalculable number of years, some of the proteins became capable of catalyzing the synthesis of new nucleic acids, new proteins, and other compounds such as polysaccharides and lipids.

Keywords

Pathologie RNA cell environment metabolism nutrition pathology protein proteins water

Authors and affiliations

  • Julien L. Van Lancker
    • 1
  1. 1.Department of PathologyU.C.L.A. School of MedicineLos AngelesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-65967-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1976
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-65969-0
  • Online ISBN 978-3-642-65967-6
  • About this book