Lymphocytic Choriomeningitis Virus and Other Arenaviruses

Symposium held at the Heinrich-Pette-Institut für experimentelle Virologie und Immunologie, Universität Hamburg, October 16–18, 1972

  • Editors
  • F. Lehmann-Grube

Table of contents

  1. Front Matter
    Pages I-XIII
  2. General Introduction

    1. Front Matter
      Pages 1-1
  3. Lymphocytic Choriomeningitis Virus

    1. Front Matter
      Pages 11-11
    2. The Virus: Purification, Chemical and Physical Properties, Complement-Fixing Antigen (s)

    3. Interaction of LCM Virus with Cells, Including New Virus-Induced Cellular Antigens

      1. G. Rutter, H. H. Gschwender
        Pages 51-59
      2. G. A. Cole, R. A. Prendergast, C. S. Henney
        Pages 61-71
      3. O. A. Holtermann, Jeaninne A. Majde
        Pages 73-81
    4. Persistent Infection in Vitro and in Vivo, Including Interference Phenomena

    5. Acute and Chronic LCM Disease in Man and Animals

About this book

Introduction

Four decades ago, lymphocytic choriomeningitis virus was discovered, at about the same time and independently, in 3 different localities in the U.S.A. Armstrong and Lillie encountered the agent in a monkey when they passaged a recent isolate of the St. Louis encephalitis virus; Rivers and Scott isolated 5 strains from patients with meningitis; and Traub revealed the virus in a colony of albino mice. Already in these first isolations mice were incriminated, and later observa­ tions proved beyond doubt that M. musculus is the principal reservoir of the virus in nature. For some time LCM virus was regarded as the sole etiologic agent of Wallgren's "meningite aseptique aigue". Soon, however, it became clear that Wallgren's syndrome had a multitude of causes, among which the LCM virus was of little relevance, and in subsequent years it disappeared from the sight of most viro­ logists. Indeed, it might have fallen into oblivion had it not been for Erich Traub who, practically all by himself, continued to investigate the intricate relationship between this virus and its natural host, the common house mouse.

Keywords

Antigen Immunologie Thymus biology cell central nervous system histocompatibility immunology immunosuppression infection infections nervous system pathogenesis virology virus

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-65681-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 1973
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-06403-9
  • Online ISBN 978-3-642-65681-1
  • About this book