Hormones and Resistance

1. Front Matter

   Pages I-XVIII

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2. Reviews

   • Hans Selye

   Pages 1-4

3. Introduction, Terminology and Classification, Methods

   • Hans Selye

   Pages 5-23

4. History

   • Hans Selye

   Pages 24-41

5. Chemistry

   • Hans Selye

   Pages 42-52

6. General Pharmacology

   • Hans Selye

   Pages 53-110

7. Effect of Steroids Upon Resistance

   • Hans Selye

   Pages 111-404

8. Effect of Other Hormones Upon Resistance

   • Hans Selye

   Pages 405-565

9. Effect of Nonhormonal Factors Upon Resistance

   • C. C. Hans Selye

   Pages 567-706

10. Clinical Implications

    • C. C. Hans Selye

    Pages 707-724

11. Morphology

    • C. C. Hans Selye

    Pages 725-742

12. Theories

    • C. C. Hans Selye

    Pages 743-767

13. Synopsis of Pharmaco-Chemical and Pharmaco-Pharmacologic Interrelations

    • C. C. Hans Selye

    Pages 768-1051

14. Back Matter

    Pages 1053-1140

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7 If so, the individual members of each class thus identified could then be subjected to a more profound pharmacokinetic analysis. In other words, we had to determine first which hormone protects against which drug, before we could explore how it did this. We had to know first that a hormone has adaptive value before we could ask whether this is due to a syntoxic or a catatoxic mechanism. Such observations, as the fact that an indomethacin-induced intestinal ulcer can be prevented by ethylestrenol, orthat cortisol aggravates certain infections, reveal nothing about how these hormones work; but only findings of this type can tell us where further research would be rewarding. Of course, scientists can rarely identify by direct observation the tbings that they are looking for; most of the time they have to be guided by indirect indices. The ebernist often first detects a compound, or even a particular functional group in its molecule, by inference from a color reaction, a revealing X-ray diffraction pattern or the formation of a characteristic precipitate. The physician must first suspect the presence of a microbe through certain clinical signs and symptoms before he can verify his diagnosis by looking for a particular organism. It is perhaps not too daring to hope that in our first efforts to clarify the role of hormones in resistance, simple, directly visible indicators might also serve us best.

• Hormones
• Resistance
• X-ray
• chemistry
• diagnosis
• drug
• hormone
• infection
• infections
• molecule
• pharmacokinetics
• pharmacology
• research

• Institut de Médecine et de Chirurgie expérimentales, Université de Montréal, Montreal, Canada

  Hans Selye