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Microsurgical Models in Rats for Transplantation Research

  • Arnulf Thiede
  • Eberhard Deltz
  • Rainer Engemann
  • Horst Hamelmann

Table of contents

  1. Front Matter
    Pages I-XIX
  2. Microsurgical Models and Techniques

  3. Immunological Principles

  4. Results of Vessel and Heart Transplantation

    1. T. Schang, B. von Gaudecker, A. Thiede
      Pages 95-100
    2. A. C. Yankah, G. Randzio, H. U. Wottge, A. Bernhard
      Pages 107-111
    3. R. G. H. Baumeister, J. Seifert, H. Liebich, B. Wiebecke, Ch. Gabka, U. Goldmann
      Pages 113-116
    4. Ch. Gabka, R. G. Baumeister, H. G. Leibich, J. Seifert, W. Brendel
      Pages 117-120
    5. J. Klempnauer, B. Steiniger, K. Wonigeit, E. Günther
      Pages 121-126
    6. W. Konertz, A. Bernhard
      Pages 127-129
  5. Results of Small-Intestine Transplantation, Graft Versus Host Reaction, and Host Versus Graft Reaction

  6. Pancreas Transplantation Versus Islet Transplantation

  7. Results of Liver Transplantation

    1. D. Houssin, J. Gugenheim, M. D. Brunaud, M. Gigou, M. Charra, S. Crougneau et al.
      Pages 227-231
    2. G. H. Müller, A. Wunderlich, U. T. Hopt, H. Bockhorn
      Pages 234-235
    3. F. A. Zimmermann, T. Schmid, Ursula Schmid, J. M. Gokel, T. Siegel, C. Hammer
      Pages 237-243
    4. N. Kamada, T. Shinomiya
      Pages 245-246
    5. R. Engemann, K. Ulrichs, A. Thiede, W. Müller-Ruchholtz, H. Hamelmann
      Pages 263-268
  8. Miscellaneous: Microsurgical Organ Transplantation

    1. G. H. Müller, A. Wunderlich, W. Schareck, U. T. Hopt, H. Bockhorn
      Pages 273-274
    2. G. Filler, J. Klempnauer, B. Steiniger, K. Wonigeit
      Pages 275-280
    3. H.-U. Gutsche, M. Lüneburg, K. H. Gnutzmann, E. Deltz, W. Niedermayer
      Pages 285-290

About these proceedings

Introduction

Preclinical experimental transplantation research that is based on microsurgical models in rats fulfills two indispensable conditions for modern organ transplanta­ tion research: Almost all organ grafts can be performed on the rat with an amount of technical effort that is still justifiable. Thus transplantation models that are analogous to human organ transplantation can be developed, tested, and evaluated. This fulfills a necessary condition from the standpoint of surgery. With the species rat, we have a great variety of genetically different inbred strains. From the immunological point of view this is an indispensable prerequisite for the investigation of preclinical transplantation models that can be expected to produce controllable, reproducible results. In vivo experimental results can be supplemented by and correlated to in vitro tests. Lately these experimental results are being greatly expanded and more precisely defined by the application of immunohistological methods that have been established recently in Kiel. In this book we hope to present a cross section of the microsurgical models in use today and of current immunological and immunohistological models. Furthermore, we wish to record the present state of microsurgical organ transplantation research and to show its relationship to the current state and development of clinical organ transplantation. A special aspect of our Kiel research group is the long-term, well-functioning, interdisciplinary cooperation between surgery, immunology, and pathology. Through this cooperation we attempt to provide an atmosphere in which theoretical and practical viewpoints can mutually influence each other.

Keywords

development histology immunology microsurgery organ organ transplantation pathology reconstructive surgery research surgery transplantation

Editors and affiliations

  • Arnulf Thiede
    • 1
  • Eberhard Deltz
    • 1
  • Rainer Engemann
    • 1
  • Horst Hamelmann
    • 1
  1. 1.Abteilung Allgemeine ChirurgieChirurgische UniversitätsklinikKiel 1Federal Republic of Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-61657-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1985
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64899-1
  • Online ISBN 978-3-642-61657-0
  • Buy this book on publisher's site