Hydroxy-Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis

1. Front Matter

   Pages I-X

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2. Hydroxy-Pyridones Outstanding Biological Properties

   • A. Markus

   Pages 1-10

3. Enzyme Histochemical Investigations of Candida albicans After Treatment with Rilopirox, a Novel Fungicidal Hydroxy-Pyridone

   • H. K. Reitze, K.-A. Seitz, D. R. Dannhorn, H. Hänel, M. Bohn

   Pages 11-17

4. Can Ciclopirox Be Used as a Broad-Spectrum Anti-Infective Agent?

   • W. Schalla, K. Kraemer, R. Pooth

   Pages 18-32

5. Studies of the Anti-Inflammatory Properties of Ciclopirox

   • J. L. Rees

   Pages 33-35

6. Measurement of Ciclopirox Permeation Through Fingernail Models by Novel Spectroscopic Techniques

   • T. M. Bayerl

   Pages 36-38

7. Dermatomycosis: A Multifactorial Disease

   • M. A. J. Allevato

   Pages 39-42

8. Efficacy of Topical Batrafen

   • S. A. Burova

   Pages 43-44

9. Ciclopirox Gel Treatment of Scalp Seborrheic Dermatitis

   • B. B. Abrams, R. J. Cherill, R. Ramaswamy, H. I. Katz

   Pages 45-50

10. Seborrhoeic Dermatitis and Dandruff, and Its Treatment With Ciclopirox Shampoo

    • S. Shuster

    Pages 51-55

11. Epidemiology of Mycological Infections in Children—in South America

    • F. M. Gonzalez Otero

    Pages 56-61

12. Clinical Efficacy of Topical Ciclopirox Nail Lacquer: Double-Blind United States Studies on Onychomycosis

    • R. Scher

    Pages 62-68

13. Dose Regimen Studies with Ciclopirox Nail Lacquer

    • G. Wozel

    Pages 69-74

14. Open Studies of Ciclopirox Nail Lacquer in Onychomycosis—A Review

    • S. Nolting

    Pages 75-80

15. Influence of Onychomycosis on the Quality of Life

    • A. Stary, S. Torma, P. G. Sator

    Pages 81-90

16. Treatment of Onychomycoses: Pharmacoeconomic Aspects

    • T. R. Einarson, P. I. Oh, N. Shear

    Pages 91-95

17. The Safety Aspects of Systemic and Topical Antifungal Agents Used in the Management of Onychomycosis

    • A. K. Gupta

    Pages 96-102

18. Differential Diagnosis of Onychomycosis and Rationale for a Step-Therapy in Treating Nail Fungal Infection

    • R. Baran

    Pages 103-109

This book summarizes the results of two symposia held on hydroxy-pyridones as antifungal agents organized on the occasion of the International Summit on Cutaneous Antifungal Therapy 1996 in Vancouver and the 19th World Congress of Dermatology 1997 in Sydney. Some of the papers deal with the basic mechanisms of action and how these translate into product features, e.g. activity spectrum. Other papers describe the unique properties of hydroxy-pyridones, such as high penetration into and through keratinic tissues or their activity as dual inhibitor on 5-lipoxygenase and cyclooxygenase which leads to a remarkable antiinflammatory effect. Last but not least various accounts are given which show how this unique product profile aids the treatment of various fungal diseases, especially onychomycosis.

• Antifungal Agents
• Ciclopirox
• Dermatitis
• Mycosis
• Mykosen
• Onychomycosis
• Pilzerkrankungen
• epidemiology
• infection
• research
• therapy

• Department of Dermatology Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne, England

  Sam Shuster

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