Skip to main content
SpringerLink
Log in
Book cover

Protein Degradation in Health and Disease

  • Book
  • © 2002

Overview

Editors:
  1. Michèle Reboud-Ravaux

    1. Laboratoire d’Enzymologie Moléculaire et Fonctionnelle Département de Biologie Cellulaire Institut Jacques Monod, Universités Paris VI & VII, Paris Cedex 05, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • A concise overview of protein degradation, unique in its perspective on both fundamental mechanisms and implications for medical research
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 29)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (7 chapters)

  1. Front Matter

    Pages I-X
    Download chapter PDF

  2. Roles of SCF and VHL Ubiquitin Ligases in Regulation of Cell Growth

    • Takumi Kamura, Joan W. Conaway, Ronald C. Conaway
    Pages 1-15

  3. Aging of Proteins and the Proteasome

    • Bertrand Friguet
    Pages 17-33

  4. Protein Degradation in the Aging Organism

    • Walter F. Ward
    Pages 35-42

  5. Protein Degradation in Alzheimer’s Disease and Aging of the Brain

    • Teruyuki Tsuji, Shun Shimohama
    Pages 43-60

  6. Protein Degradation in Human Disease

    • Richard K. Plemper, Anthea L. Hammond
    Pages 61-84

  7. The 26S Proteasome

    • Olivier Coux
    Pages 85-107

  8. Proteasome Inhibitors

    • Michèle Reboud-Ravaux
    Pages 109-125

  9. Back Matter

    Pages 127-130
    Download chapter PDF
Back to top

Keywords

About this book

Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Editors and Affiliations

  • Laboratoire d’Enzymologie Moléculaire et Fonctionnelle Département de Biologie Cellulaire Institut Jacques Monod, Universités Paris VI & VII, Paris Cedex 05, France

    Michèle Reboud-Ravaux

Bibliographic Information

  • Book Title: Protein Degradation in Health and Disease

  • Editors: Michèle Reboud-Ravaux

  • Series Title: Progress in Molecular and Subcellular Biology

  • DOI: https://doi.org/10.1007/978-3-642-56373-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2002

  • Hardcover ISBN: 978-3-540-42594-6Published: 22 January 2002

  • Softcover ISBN: 978-3-642-62714-9Published: 05 November 2012

  • eBook ISBN: 978-3-642-56373-7Published: 06 December 2012

  • Series ISSN: 0079-6484

  • Series E-ISSN: 2197-8484

  • Edition Number: 1

  • Number of Pages: X, 130

  • Topics: Cell Biology, Biochemistry, general, Cancer Research

Publish with us

Policies and ethics

Back to top

Search

Navigation