Skip to main content
  • Book
  • © 2014

Developments in Statistical Evaluation of Clinical Trials

  • Provides an overview of important statistical methods used in clinical trials

  • Chapters supplemented with a discussion of practical applications

  • Up-to-date reference for researchers and practitioners involved with clinical trials

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-3-642-55345-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)

This is a preview of subscription content, access via your institution.

Table of contents (18 chapters)

  1. Front Matter

    Pages i-xi
  2. Statistical Approaches to Improving Trial Efficiency and Conduct

    • Janice Pogue, P. J. Devereaux, Salim Yusuf
    Pages 71-84
  3. Competing Risks and Survival Analysis

    • Kees van Montfort, Peter Fennema, Wendimagegn Ghidey
    Pages 85-96
  4. Recent Developments in Group-Sequential Designs

    • James M. S. Wason
    Pages 97-118
  5. Design and Analysis of Clinical Trial Simulations

    • Kazuhiko Kuribayashi
    Pages 139-151
  6. Statistical Validation of Surrogate Markers in Clinical Trials

    • Ariel Alonso, Geert Molenberghs, Gerard van Breukelen
    Pages 227-246
  7. Biomarker-Based Designs of Phase III Clinical Trials for Personalized Medicine

    • Shigeyuki Matsui, Takahiro Nonaka, Yuki Choai
    Pages 247-263
  8. Dose-Finding Methods for Two-Agent Combination Phase I Trials

    • Akihiro Hirakawa, Shigeyuki Matsui
    Pages 265-282
  9. Multi-state Models Used in Oncology Trials

    • Birgit Gaschler-Markefski, Karin Schiefele, Julia Hocke, Frank Fleischer
    Pages 283-304

About this book

This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials.

Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.

Keywords

  • clinical trials
  • dose adjustment
  • survival analysis

Editors and Affiliations

  • Department of Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands

    Kees van Montfort

  • Behavioural Science Institute, University of Nijmegen, Nijmegen, The Netherlands

    Johan Oud

  • Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands

    Wendimagegn Ghidey

Bibliographic Information

  • Book Title: Developments in Statistical Evaluation of Clinical Trials

  • Editors: Kees van Montfort, Johan Oud, Wendimagegn Ghidey

  • DOI: https://doi.org/10.1007/978-3-642-55345-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Mathematics and Statistics, Mathematics and Statistics (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2014

  • Hardcover ISBN: 978-3-642-55344-8

  • Softcover ISBN: 978-3-662-52211-0

  • eBook ISBN: 978-3-642-55345-5

  • Edition Number: 1

  • Number of Pages: XI, 361

  • Number of Illustrations: 61 b/w illustrations

  • Topics: Statistical Theory and Methods, Biostatistics

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-3-642-55345-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)