Receptor/Ligand Sorting Along the Endocytic Pathway

  • Jennifer J. Linderman
  • Douglas A. Lauffenburger

Part of the Lecture Notes in Biomathematics book series (LNBM, volume 78)

Table of contents

  1. Front Matter
    Pages I-VI
  2. Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 1-2
  3. Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 3-17
  4. Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 18-21
  5. Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 22-55
  6. Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 56-79
  7. Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 80-129
  8. Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 130-133
  9. Back Matter
    Pages 134-166

About this book

Introduction

This research monograph focuses on a biomolecular separation process that occurs within most cells. Two types of molecules, receptors and ligands, are separated and routed along different intracellular pathways; this is a critical step in the process of receptor-mediated endocytosis. The development of an understanding of the basic mechanisms of this separation process is presented, with an emphasis on discovering the fundamental and measurable parameters that influence the event. Mathematical models of sorting are evaluated to predict the range of possible outcomes. These are compared with a variety of experimental data on different receptor/ligand systems. In addition, the influence of the separation on overall receptor/ligand processing dynamics is discussed. The book is intended for both biomathematicians and biologists. It is not necessary to understand the details of the model equations and their solution in order to test the models experimentally. The analysis suggests experiments that might be done to further investigate the sorting process and the text details methods for analyzing these experimental results.

Keywords

Mathematica cell cells development dynamics experiment influence molecule receptor receptors system

Authors and affiliations

  • Jennifer J. Linderman
    • 1
  • Douglas A. Lauffenburger
    • 2
  1. 1.Department of Chemical EngineeringUniversity of MichiganAnn ArborUSA
  2. 2.Department of Chemical EngineeringUniversity of PennsylvaniaPhiladelphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-48892-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 1989
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-50849-6
  • Online ISBN 978-3-642-48892-4
  • Series Print ISSN 0341-633X
  • About this book