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Biological Markers of Alzheimer’s Disease

  • Conference proceedings
  • © 1989

Overview

Editors:
  1. François Boller

    1. Inserm U324, Paris, France

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  2. Robert Katzman

    1. University of California at San Diego, La Jolla, USA

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  3. André Rascol

    1. Hôpital Purpan, Toulouse, France

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  4. Jean-Louis Signoret

    1. Hôpital Salpêtrière, Paris, France

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  5. Yves Christen

    1. Fondation IPSEN pour la Recherche Thérapeutique, Paris Cédex, France

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Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (17 papers)

  1. Front Matter

    Pages I-XV
    Download chapter PDF

  2. Cerebrospinal Fluid Neurochemical Markers in Alzheimer’s Disease

    • J. R. Atack
    Pages 1-16

  3. Potential Diagnostic Markers for Alzheimer’s Disease

    • P. Davies
    Pages 17-22

  4. Cerebrospinal Fluid-Based Laboratory Test for Alzheimer’s Disease

    • H. M. Wisniewski, P. D. Mehta, K. S. Kim, G. S. Merz
    Pages 23-29

  5. Probes for the Molecular Components of Plaques and Tangles Point to a Broadening View of Alzheimer Pathology

    • K. S. Kosik, D. J. Selkoe
    Pages 30-38

  6. Tau 64 and Tau 69: Two Early Biochemical Markers of Neurofibrillary Degeneration

    • A. Delacourte, S. Flament, A. Défossez, L. Buee, B. Hémon, M. Parent et al.
    Pages 39-55

  7. A cDNA Encodes Epitopes Shared Between Microtubule-Associated Protein MAP2 and Alzheimer Neurofibrillary Tangles: In Situ Hybridization and Immunocytochemistry

    • J. P. Brion, A. M. Couck, M. E. Cheetham, D. Hanger, B. H. Anderton, J. Flament-Durand
    Pages 56-65

  8. Epitopes Characteristic of Paired Helical Filaments Demonstrated in Microglial Cells and Macrophages of the Meninges: A Possible Laboratory Diagnosis of Alzheimer’s Disease from Cerebrospinal Fluid?

    • J. Ulrich, S. Ipsen, A. Probst, J. P. Brion
    Pages 66-72

  9. Relationship Between Tau, Paired Helical Filaments, Amyloid and the Intellectual Deterioration in the Neocortex in Normal Aging and in Senile Dementia of the Alzheimer Type

    • P. Delaère, C. Duyckaerts, J. P. Brion, F. Piette, J.-J. Hauw
    Pages 73-82

  10. Molecular Insights into Alzheimer’s Disease

    • J. W. Pettegrew
    Pages 83-104

  11. Altered Protein Kinase and Amyloid ß-Protein Precursor in Alzheimer’s Disease: Which Comes First?

    • T. Saitoh, D. S. Iimoto
    Pages 105-117

  12. The Amyloid Gene of Alzheimer’s Disease and Neuronal Dysfunction

    • J. M. Salbaum, C. L. Masters, K. Beyreuther
    Pages 118-122

  13. Cloning of Different Amyloid Peptide Precursors from Brains of Patients with Alzheimer’s Disease

    • F. de Sauvage, A. F. Macq, J. M. Maloteaux, J. N. Octave
    Pages 123-129

  14. Genetic Studies of the Alzheimer’s Disease-Associated Amyloid β-Protein Precursor Gene and Familial Alzheimer’s Disease

    • R. E. Tanzi, P. St. George-Hyslop, M. James, J. L. Haines, J. F. Gusella
    Pages 130-137

  15. Alzheimer’s Disease and Chromosome 21

    • A. R. Haynes, M. J. Owen, A. M. Goate, L. A. James, M. J. Mullan, R. Williamson et al.
    Pages 138-145

  16. Calcium and the Cytoskeleton in Alzheimer’s Disease

    • M. L. Shelanski
    Pages 146-152

  17. Use of Cultured Skin Fibroblasts in Studies of Alzheimer’s Disease

    • J. P. Blass, A. C. Baker, K.-F. R. Sheu, L. Ko, R. S. Black, A. Smith
    Pages 153-162

  18. Lactate Production and Glycolytic Enzymes in Skin Cultured Cells from Alzheimer’s Disease Patients

    • S. Sorbi, M. Mortilla, S. Piacentini, G. Tesco, S. Tonini, L. Amaducci
    Pages 163-166

  19. Back Matter

    Pages 167-169
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Keywords

About this book

This volume presents the proceedings of the symposium held in Toulouse on April 24, 1989, on the topic "Biological Markers of Alzheimer's Disease. " This sym­ posium was the fourth of a continuing and successful series of Colloques Medecine et Recherche organized by the Fondation IPSEN pour la Recherche Therapeutique, addressing various aspects of contemporary research in the field of Alzheimer's disease (AD). The series started in September 1987 with "Im­ munology and Alzheimer's Disease," followed 6 months later in Paris by "Gene­ tics and Alzheimer's Disease" and in September 1988 in Montpellier by "Neuronal Grafting and Alzheimer's Disease. " The present symposium was organized for the purpose of gathering the most current ideas concerning biological markers of AD. The papers presented at this symposium may be roughly subdivided into three groups. The first deals with the markers of AD at the level of the brain itself. These markers are studied either through the cerebrospinal fluid or through techniques such as nuclear magnetic resonance (NMR) - approaches which respectively aim at demonstrating the cerebral changes indicated by the debris resulting from the disease, or studying the possible neurochemical abnormalities that occur in the earlier stages of AD.

Editors and Affiliations

  • Inserm U324, Paris, France

    François Boller

  • University of California at San Diego, La Jolla, USA

    Robert Katzman

  • Hôpital Purpan, Toulouse, France

    André Rascol

  • Hôpital Salpêtrière, Paris, France

    Jean-Louis Signoret

  • Fondation IPSEN pour la Recherche Thérapeutique, Paris Cédex, France

    Yves Christen

Bibliographic Information

  • Book Title: Biological Markers of Alzheimer’s Disease

  • Editors: François Boller, Robert Katzman, André Rascol, Jean-Louis Signoret, Yves Christen

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-642-46690-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1989

  • Softcover ISBN: 978-3-642-46692-2Published: 01 March 2012

  • eBook ISBN: 978-3-642-46690-8Published: 08 March 2013

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: XV, 169

  • Topics: Neurology, Neurosciences

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