Fundamentals of Evidence-Based Health Care and Translational Science

  • Francesco Chiappelli

Table of contents

  1. Front Matter
    Pages i-xxvii
  2. Fundamental Implications for Clinical Practice

  3. Optimizing Clinical Practice-Based Patient-Centered Outcomes Research

    1. Front Matter
      Pages 155-155
    2. Francesco Chiappelli
      Pages 157-199
    3. Francesco Chiappelli
      Pages 201-228
    4. Francesco Chiappelli
      Pages 229-267
    5. Francesco Chiappelli
      Pages 269-290
    6. Francesco Chiappelli
      Pages 311-323
  4. Back Matter
    Pages 361-394

About this book


Comparative effectiveness research – the conduct and synthesis of systematic research in order to compare the benefits and harms of alternative treatment options – is of critical importance in enabling informed health care decisions to be made. This user-friendly, practical handbook examines in depth how best to perform such comparative effectiveness research. A wide range of topics and methods are discussed, including research synthesis, sampling analysis, assessment of evidence design, systematic evaluation of statistical analysis, and meta-analysis. The discussion extends well beyond the fundamentals by encompassing “complex” systematic reviews, “cumulative” meta-analyses, and logic-based versus utility-based decision making. Health care providers, researchers, instructors, and students will all find this to be an invaluable reference on the compelling current issues and important analytical tools in comparative effectiveness research.


level of evidence meta-analysis research synthesis systematic review

Authors and affiliations

  • Francesco Chiappelli
    • 1
  1. 1.CHS 63-090UCLA School of DentistryLos AngelesUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-41856-3
  • Online ISBN 978-3-642-41857-0
  • Buy this book on publisher's site