Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism

  • Jean Pieters
  • John D. McKinney

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 374)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Digby F. Warner, Tone Tønjum, Valerie Mizrahi
    Pages 27-51
  3. Tasha Smith, Kerstin A. Wolff, Liem Nguyen
    Pages 53-80
  4. John D. Szumowski, Kristin N. Adams, Paul H. Edelstein, Lalita Ramakrishnan
    Pages 81-108
  5. Aniek D. van der Woude, Joen Luirink, Wilbert Bitter
    Pages 109-134
  6. Rajesh Jayachandran, Somdeb BoseDasgupta, Jean Pieters
    Pages 189-209
  7. Sarah A. Stanley, Jeffery S. Cox
    Pages 211-241
  8. Back Matter
    Pages 243-245

About this book


Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms.

In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.


Drug resistance Host-pathogen interaction Macrophages Microbial infection Tuberculosis

Editors and affiliations

  • Jean Pieters
    • 1
  • John D. McKinney
    • 2
  1. 1.BiozentrumUniversity of BaselBaselSwitzerland
  2. 2.Laboratory of Microbiology and MicrosystemsSwiss Federal Institute of Technology Lausanne (EPFL)LausanneSwitzerland

Bibliographic information