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Nucleic Acid Polymerases

  • Book
  • © 2014

Overview

Editors:
  1. Katsuhiko S. Murakami

    1. Dept. of Biochem. and Mol. Biology, The Pennsylvania State University, University Park, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Michael A. Trakselis

    1. Department of Chemistry, University of Pittsburgh, Pittsburgh, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a comprehensive review of the multitude of nucleic acid polymerases
  • Catalogs all nucleic acid polymerases
  • Written by polymerase fans for polymerase fans?
  • Includes supplementary material: sn.pub/extras

Part of the book series: Nucleic Acids and Molecular Biology (NUCLEIC, volume 30)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. Introduction to Nucleic Acid Polymerases: Families, Themes, and Mechanisms

    • Michael A. Trakselis, Katsuhiko S. Murakami
    Pages 1-15

  3. Eukaryotic Replicative DNA Polymerases

    • Erin Walsh, Kristin A. Eckert
    Pages 17-41

  4. DNA Repair Polymerases

    • Robert W. Sobol
    Pages 43-83

  5. Eukaryotic Y-Family Polymerases: A Biochemical and Structural Perspective

    • John M. Pryor, Lynne M. Dieckman, Elizabeth M. Boehm, M. Todd Washington
    Pages 85-108

  6. DNA Polymerases That Perform Template-Independent DNA Synthesis

    • Anthony J. Berdis
    Pages 109-137

  7. Archaeal DNA Polymerases: Enzymatic Abilities, Coordination, and Unique Properties

    • Michael A. Trakselis, Robert J. Bauer
    Pages 139-162

  8. Engineered DNA Polymerases

    • Roberto Laos, Ryan W. Shaw, Steven A. Benner
    Pages 163-187

  9. Reverse Transcriptases

    • Stuart F. J. Le Grice, Marcin Nowotny
    Pages 189-214

  10. Telomerase: A Eukaryotic DNA Polymerase Specialized in Telomeric Repeat Synthesis

    • Andrew F. Brown, Joshua D. Podlevsky, Julian J.-L. Chen
    Pages 215-235

  11. Bacteriophage RNA Polymerases

    • Ritwika S. Basu, Katsuhiko S. Murakami
    Pages 237-250

  12. Mitochondrial DNA and RNA Polymerases

    • Y. Whitney Yin
    Pages 251-275

  13. Eukaryotic RNA Polymerase II

    • David A. Bushnell, Roger D. Kornberg
    Pages 277-287

  14. Plant Multisubunit RNA Polymerases IV and V

    • Thomas S. Ream, Jeremy R. Haag, Craig S. Pikaard
    Pages 289-308

  15. Structure, Dynamics, and Fidelity of RNA-Dependent RNA Polymerases

    • David D. Boehr, Jamie J. Arnold, Ibrahim M. Moustafa, Craig E. Cameron
    Pages 309-333

  16. Back Matter

    Pages 335-342
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Keywords

About this book

This book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme. Although many books cover several different types of polymerases, no book so far has attempted to catalog all nucleic acid polymerases. The goal of this book is to be the top reference work for postgraduate students, postdocs, and principle investigators who study polymerases of all varieties. In other words, this book is for polymerase fans by polymerase fans.

Nucleic acid polymerases play a fundamental role in genome replication, maintenance, gene expression and regulation. Throughout evolution these enzymes have been pivotal in transforming life towards RNA self-replicating systems as well as into more stable DNA genomes. These enzymes are generally extremely efficient and accurate in RNA transcription and DNA replication and share common kinetic and structural features. How catalysis can be so amazingly fast without loss of specificity is a question that has intrigued researchers for over 60 years. Certain specialized polymerases that play a critical role in cellular metabolism are used for diverse biotechnological applications and are therefore an essential tool for research.

Editors and Affiliations

  • Dept. of Biochem. and Mol. Biology, The Pennsylvania State University, University Park, USA

    Katsuhiko S. Murakami

  • Department of Chemistry, University of Pittsburgh, Pittsburgh, USA

    Michael A. Trakselis

Bibliographic Information

  • Book Title: Nucleic Acid Polymerases

  • Editors: Katsuhiko S. Murakami, Michael A. Trakselis

  • Series Title: Nucleic Acids and Molecular Biology

  • DOI: https://doi.org/10.1007/978-3-642-39796-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2014

  • Hardcover ISBN: 978-3-642-39795-0Published: 31 October 2013

  • Softcover ISBN: 978-3-662-50998-2Published: 23 August 2016

  • eBook ISBN: 978-3-642-39796-7Published: 22 October 2013

  • Series ISSN: 0933-1891

  • Series E-ISSN: 1869-2486

  • Edition Number: 1

  • Number of Pages: VIII, 342

  • Number of Illustrations: 23 b/w illustrations, 53 illustrations in colour

  • Topics: Enzymology, Nucleic Acid Chemistry, Gene Expression, Cell Biology

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