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Disruption of Protein-Protein Interfaces

In Search of New Inhibitors

  • Stefano Mangani

Table of contents

  1. Front Matter
    Pages i-vii
  2. Laura Bettinetti, Matteo Magnani, Alessandro Padova
    Pages 1-29
  3. Stefania Ferrari, Federica Pellati, Maria Paola Costi
    Pages 31-60
  4. Simon Cross, Massimo Baroni, Francesco Ortuso, Stefano Alcaro, Gabriele Cruciani
    Pages 61-82
  5. Rebecca Del Conte, Daniela Lalli, Paola Turano
    Pages 83-111
  6. Back Matter
    Pages 159-161

About this book

Introduction

"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.

Keywords

Dissociative inhibition model Drug discovery Inhibitors design Inhibitors of protein-protein interactions Interface directed inhibitors Ligand binding sites at protein interfaces Protein-protein interfaces as drug targets Quaternary structure inhibitors

Editors and affiliations

  • Stefano Mangani
    • 1
  1. 1., Department of Biotechnology, Chemistry aUniversity of SienaSienaItaly

Bibliographic information