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Evolution of Extracellular Matrix

  • Book
  • © 2013

Overview

  • Gives a comprehensive and up to date overview on the field
  • Written by experts in the field
  • First book to look in detail on the evolution of ECM
  • Includes supplementary material: sn.pub/extras

Part of the book series: Biology of Extracellular Matrix (BEM)

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About this book

The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function.  This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.

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Table of contents (10 chapters)

Editors and Affiliations

  • Hospital for Sick Children, Toronto, Canada

    Fred W. Keeley

  • Dept. Cell Biology & Physiology, Washington University School of Medicine, St. Louis, USA

    Robert P. Mecham

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