Myeloproliferative Neoplasms

Critical Concepts and Management

  • Tiziano Barbui
  • Ayalew Tefferi

Part of the Hematologic Malignancies book series (HEMATOLOGIC)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Biology

    1. Front Matter
      Pages 1-1
    2. Moosa Qureshi, Claire Harrison
      Pages 11-16
  3. General Issues in the Management of MPNs

    1. Front Matter
      Pages 17-17
    2. Jürgen Thiele, Hans Michael Kvasnicka
      Pages 19-35
    3. Anna Falanga, Laura Russo, Marina Marchetti
      Pages 57-67
  4. Specific Issues of Treatment in PV and ET

  5. Treatment of PMF

  6. Research Issues and Perspectives

    1. Front Matter
      Pages 201-201
    2. Fabio P. S. Santos, Srdan Verstovsek
      Pages 215-232
  7. Back Matter
    Pages 233-240

About this book


Myeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of these diseases have arisen following the discovery of the JAK2 V617F mutation in the majority of patients with bcr/abl-negative MPNs.


This book comprises evidence-based reviews and expert consensus results. It offers comprehensive coverage of relevant laboratory and clinical advances and places great emphasis on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic  approaches, the value and limitations of mutation screening for diagnostic and  prognostic purposes, risk stratification in terms of both survival and other  disease complications such as leukemic transformation and thrombosis, and  modern therapeutic strategies, including conventional drugs, allogeneic stem cell  transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.


Myeloproliferative Neoplasms Polycythemia Vera Primary Myelofibrosis Thrombocythemia

Editors and affiliations

  • Tiziano Barbui
    • 1
  • Ayalew Tefferi
    • 2
  1. 1.Div. EmatologiaOspedali Riuniti di BergamoBergamoItaly
  2. 2.Dept. Internal Medicine, Div. HematologyMayo ClinicRochesterUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-24988-4
  • Online ISBN 978-3-642-24989-1
  • Buy this book on publisher's site