Biomechanics and Mechanobiology of Aneurysms

  • Tim McGloughlin

Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 7)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Natzi Sakalihasan, Helena Kuivaniemi, Betty Nusgens, Rodolphe Durieux, Jean-Olivier Defraigne
    Pages 1-33
  3. Peter Hoskins, Scott Semple, Phil White, Jennifer Richards
    Pages 35-65
  4. Julie A. Phillippi, Salvatore Pasta, David A. Vorp
    Pages 67-118
  5. Barry J. Doyle, Timothy M. McGloughlin
    Pages 119-138
  6. Madhavan L. Raghavan, Erasmo Simão da Silva
    Pages 139-162
  7. David S. Molony, Stephen Broderick, Anthony Callanan, Tim M. McGloughlin, Michael T. Walsh
    Pages 163-179
  8. Timothy Corbett, David Molony, Eamon Kavanagh, Pierce Grace, Michael Walsh, Tim McGloughlin
    Pages 247-284
  9. Moqueet A. Qureshi, Brain D. Conway, Roy K. Greenberg
    Pages 285-329
  10. Manik Mehra, Gabriela Spilberg, Matthew J. Gounis, Ajay K. Wakhloo
    Pages 331-372
  11. Paul N. Watton, Yiannis Ventikos, Gerhard A. Holzapfel
    Pages 373-399
  12. Darren Haskett, Mohamad Azhar, Jonathan P. Vande Geest
    Pages 401-421
  13. Back Matter
    Pages 423-424

About this book

Introduction

Cardiovascular disease is the leading cause of morbidity and premature death of modern era medicine. It is estimated that approximately 81 million people in the United States (US) currently have one or more of the many forms of cardiovascular disease, resulting in 1 in every 2.8 deaths, or 900,000 deaths per year. 40% of all deaths in Europe are a result of cardiovascular disease in people under the age of 75.  Aneurysms form a significant portion of these cardiovascular related deaths and are defined as a permanent and irreversible localised dilation of a blood vessel greater than 50% of its normal diameter. Although aneurysms can form in any blood vessel, the more lethal aneurysms develop in the cranial arteries, and in the thoracic aorta and abdominal aorta. Frequently aneurysms are undetected and if left untreated may eventually expand until rupture with very high levels of morbidity and mortality. The biomechanics and mechanobiology of aneursymal diseases are not fully understood and this monograph aims to provide new insights into aneurysm aetiology and behavior based on the most recent biomechanics research related to this important topic. The contributors to this volume bring together a unique blend of expertise in experimental, computational and tissue biomechanics relating to aneurysm behavior and enable the reader to gain a fresh understanding of key factors influencing aneurysm behavior and treatment. Biological risk factors such as tobacco smoking, sex, age, hypertension, family history and mechanobiological risk factors such as aneurysm geometry and shape as well as mechanical properties of the diseased tissues are considered in detail as are many of the diagnostic and treatment options.

Keywords

abdominal aorta aetiology aneurysm clinical treatments biomechanics endovascular repair experimental and animal modeling intracranial rupture modeling solid and fluid structure interaction thoracic aorta

Editors and affiliations

  • Tim McGloughlin
    • 1
  1. 1.Dept. Mechanical and Aerospace, EngineeringUniversity LimerickLimerickIreland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-18095-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Engineering
  • Print ISBN 978-3-642-18094-1
  • Online ISBN 978-3-642-18095-8
  • Series Print ISSN 1868-2006
  • Series Online ISSN 1868-2014
  • About this book