Small-Molecule Inhibitors of Protein-Protein Interactions

  • Lyubomir Vassilev
  • David Fry

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 348)

Table of contents

  1. Front Matter
    Pages i-x
  2. Peter W. White, Anne-Marie Faucher, Nathalie Goudreau
    Pages 61-88
  3. Binh T. Vu, Lyubomir Vassilev
    Pages 151-172
  4. Back Matter
    Pages 173-174

About this book

Introduction

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In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field.

Keywords

HPV11 HPV16 HPV18 HPV6 IL-2/IL-2R MDM2 XIAP alpha-helix mimicry apoptosis beta-strand/beta-sheet mimicry c-Myc p53 pro-angiogenic signaling molecule

Editors and affiliations

  • Lyubomir Vassilev
    • 1
  • David Fry
    • 2
  1. 1.Roche Research Center, Dept. Discovery OncologyHoffmann-La Roche Inc.NutleyUSA
  2. 2.Roche Research Center, Dept. of Discovery OncologyHoffmann-La Roche Inc.NutleyUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-17083-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-17082-9
  • Online ISBN 978-3-642-17083-6
  • Series Print ISSN 0070-217X
  • About this book