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Targeting Functional Centers of the Ribosome

  • Chen┬áDavidovich

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Chen Davidovich
    Pages 1-17
  3. Chen Davidovich
    Pages 19-30
  4. Chen Davidovich
    Pages 31-54
  5. Chen Davidovich
    Pages 55-74

About this book

Introduction

This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.

Keywords

Peptidyl Transferase Center cross-resistance pleuromutilin antibiotics proto-ribosome ribosome evolution

Authors and affiliations

  • Chen┬áDavidovich
    • 1
  1. 1., Dept. of Structural BiologyThe Weizmann Insitute of ScienceRehovotIsrael

Bibliographic information