Extracellular Matrix Degradation

  • William C. Parks
  • Robert P. Mecham

Part of the Biology of Extracellular Matrix book series (BEM, volume 2)

Table of contents

  1. Front Matter
    Pages i-x
  2. Dieter Brömme, Susan Wilson
    Pages 23-51
  3. Thomas H. Bugge, Niels Behrendt
    Pages 53-74
  4. Judith S. Bond, Timothy R. Keiffer, Qi Sun
    Pages 75-94
  5. Elena I. Deryugina, James P. Quigley
    Pages 145-191
  6. A. McGarry Houghton, Majd Mouded, Steven D. Shapiro
    Pages 217-249
  7. Back Matter
    Pages 251-255

About this book


Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.


Collagen Proteases Proteoglycans Proteolysis

Editors and affiliations

  • William C. Parks
    • 1
  • Robert P. Mecham
    • 2
  1. 1.Center for Lung BiologyUniversity of WashingtonSeattleUSA
  2. 2.School of Medicine, Dept. Cell Biology & PhysiologyWashington UniversitySt. LouisUSA

Bibliographic information