NF-kB in Health and Disease

  • Michael Karin

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 349)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Tom Huxford, Alexander Hoffmann, Gourisankar Ghosh
    Pages 1-24
  3. Sandhya Ganesan, Kamna Aggarwal, Nicholas Paquette, Neal Silverman
    Pages 25-60
  4. Gilles Courtois, Alain Israël
    Pages 73-95
  5. Véronique Baud, Emmanuel Derudder
    Pages 97-114
  6. Anurupa Dev, Shankar Iyer, Bahram Razani, Genhong Cheng
    Pages 115-143
  7. Lars Eckmann, Andrew S. Neish
    Pages 145-158
  8. Melek C. Arkan, Florian R. Greten
    Pages 159-169
  9. Toby Lawrence
    Pages 171-184
  10. Shlomi Finkin, Eli Pikarsky
    Pages 185-196
  11. Shao-Cong Sun, Ethel Cesarman
    Pages 197-244
  12. Thomas D. Gilmore, Michael R. Garbati
    Pages 245-263
  13. Back Matter
    Pages 265-268

About this book

Introduction

This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system.

Keywords

NEMO molecule cell survival inflammatory gene expression mucosal homeostasis oncogenic viruses regulation of NF-kB signalling tumor-associated macrophages

Editors and affiliations

  • Michael Karin
    • 1
  1. 1.School of Medicine, Dept. PharmacologyUniversity of California, San DiegoLa JollaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-16017-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-16016-5
  • Online ISBN 978-3-642-16017-2
  • Series Print ISSN 0070-217X
  • About this book