Behavioral Neurobiology of Bipolar Disorder and its Treatment

  • Husseini K. Manji
  • Carlos A. Zarate Jr.

Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 5)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Philip B. Mitchell, Dusan Hadzi-Pavlovic, Colleen K. Loo
    Pages 1-18
  3. Jens R. Wendland, Francis J. McMahon
    Pages 19-30
  4. Tarang Khare, Mrinal Pal, Arturas Petronis
    Pages 31-49
  5. David C. Glahn, Katherine E. Burdick
    Pages 51-67
  6. Guang Chen, Ioline D. Henter, Husseini K. Manji
    Pages 89-106
  7. Espen Walderhaug, Monica Varga, Michelle San Pedro, Jian Hu, Alexander Neumeister
    Pages 107-126
  8. Jeremy W. Gawryluk, L. Trevor Young
    Pages 139-165
  9. Jing Du, Rodrigo Machado-Vieira, Rushaniya Khairova
    Pages 167-185
  10. Jonathan Savitz, Wayne C. Drevets
    Pages 201-225
  11. Benjamin N. Blond, Hilary P. Blumberg
    Pages 227-245
  12. Colleen Loo, Benjamin Greenberg, Philip Mitchell
    Pages 285-302
  13. Rodrigo Machado-Vieira, Husseini K. Manji, Carlos A. Zarate Jr.
    Pages 303-329
  14. Husseini K. Manji, Ioline D. Henter, Carlos A. Zarate Jr.
    Pages 331-340
  15. Back Matter
    Pages 341-347

About this book


Despite the devastating impact of bipolar disorder on the lives of millions worldwide, many aspects of its underlying etiology and pathophysiology remain unknown. This book, which has assembled a widely respected group of preclinical and clinical researchers, acts as a valuable and timely resource for both researchers and clinicians. This volume reviews the very latest biological, psychopharmacological, and therapeutic literature that has dominated the field in recent years and incorporates cutting-edge translational research. Early chapters review the course and outcome and genetics of this highly heritable condition, including chapters on epigenetics and clinical endophenotypes. Several chapters offer a remarkably thorough and unique overview of the neurobiology of the disorder, including what is known from genetics, molecular neurobiology, neuroimaging, and the development of animal models. Finally, the book covers treatment strategies for bipolar disorder, including both traditional and novel therapeutics, as well as non-pharmacological treatments. This book offers the unique advantages of combining in-depth coverage of current scientific knowledge with practical clinical advice and an invaluable eye toward the future of the field.


Bipolar Disorder Depression Mania Neurobiology Review

Editors and affiliations

  • Husseini K. Manji
    • 1
  • Carlos A. Zarate Jr.
    • 2
  1. 1.Research & Development, LLCJohnson & Johnson PharmaceuticalTitusvilleUSA
  2. 2.Mark O. Hatfield Clinical Res. Center, Lab. of Molecular PathophysiologyNational Institute of Mental HealthBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-15756-1
  • Online ISBN 978-3-642-15757-8
  • Series Print ISSN 1866-3370
  • Series Online ISSN 1866-3389
  • About this book