Mitochondrial Genetics and Cancer

  • Gabriel D. Dakubo

Table of contents

  1. Front Matter
    Pages i-xv
  2. General Overview of Mitochondrial Genetics and Functions

  3. Mitochondrial Genetic Alterations in Cancer

  4. Clinical Applications of Mitochondrial Genome Changes in Cancer

  5. Back Matter
    Pages 345-356

About this book


The pivotal role of mitochondrial functions in carcinogenesis is quite well established. However, the critical role of mitochondrial genome alterations to cancer development is muted in traditional textbooks. Recent scientific efforts have provided unequivocal evidence for mitochondrial genome mutations and content changes in cancer development, progression, and therapy. This pioneering book is a unique compilation of mitochondrial genome alterations in cancer. While primarily focused on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways, attention is also given to the metabolic transformations of the cancer cell, as well as the established altered cell death processes that underlie cancer evolution and treatment resistance.


DNA apoptosis cancer therapy carcinogenesis genetics mitochondrial genome mutations tissue

Authors and affiliations

  • Gabriel D. Dakubo
    • 1
  1. 1.Genesis Genomics, Inc.Thunder BayCanada

Bibliographic information