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Laron Syndrome - From Man to Mouse

Lessons from Clinical and Experimental Experience

  • Zvi Laron
  • J. Kopchick

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Clinical Aspects

    1. Front Matter
      Pages 1-1
    2. Zvi Laron
      Pages 27-28
    3. Orit Shevah, Zvi Laron
      Pages 29-52
    4. Zvi Laron
      Pages 53-57
    5. Zvi Laron, Rivka Kauli
      Pages 59-62
    6. Zvi Laron, Rivka Kauli
      Pages 101-118
    7. Zvi Laron, Shira Ginsberg, Nahum Vaisman
      Pages 135-142
    8. Zvi Laron, Hannah Kanety
      Pages 157-160
    9. Yoram Epstein, Amir Hadid, Zvi Laron, Daniel S. Moran, Nahum Vaisman
      Pages 171-174
    10. Liora Kornreich, Zvi Laron
      Pages 175-199
    11. Dan H. Bourla, Dov Weinberger
      Pages 201-208
    12. Zvi Laron, Omer Zarchi, Joseph Attias
      Pages 209-212
    13. Zvi Laron, Tsvia Karmon
      Pages 273-281
    14. Mickey Scheinowitz, Micha S. Feinberg, Michael Shechter, Zvi Laron, Rivka Kauli
      Pages 293-305
    15. Zvi Laron, Rivka Kauli, Eyal Rosenzweig
      Pages 317-320
    16. Zvi Laron
      Pages 321-322
    17. Zvi Laron, Rivka Kauli
      Pages 323-324

About this book

Introduction

Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.

Keywords

Effects on Aging GH inactivity GH insensitivity GH receptor gene disruption GH resistance IGF-treatment Laron Syndrome Metabolic Effects

Editors and affiliations

  • Zvi Laron
    • 1
  • J. Kopchick
    • 2
  1. 1.Endocrinology & Diabetes Research UnitSchneider Children's HospitalPetah TikvaIsrael
  2. 2.Edison Biotechnology InstituteOhio UniversityAthensUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-11183-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-11182-2
  • Online ISBN 978-3-642-11183-9
  • Buy this book on publisher's site