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IGFs:Local Repair and Survival Factors Throughout Life Span

  • David Clemmons
  • Iain C.A.F. Robinson
  • Yves Christen

Table of contents

  1. Front Matter
    Pages i-xiii
  2. David R. Clemmons, Laura A Maile, Walker H Busby Jr, Timothy Nichols, Yan Ling, Jarkaslava Lieskovska et al.
    Pages 11-20
  3. HoangDinh Huynh, Megan Kaba, Sonali Rudra, Junke Zheng, Catherine J. Wu, Harvey F. Lodish et al.
    Pages 21-41
  4. Robert C. Baxter, Mike Lin, Janet L. Martin
    Pages 59-68
  5. Gary Ruvkun, Andrew V. Samuelson, Christopher E. Carr, Sean P. Curran, David E. Shore
    Pages 69-84
  6. Ruslan Novosyadlyy, Emily J. Gallagher, Derek LeRoith
    Pages 97-104
  7. Sebastian Grönke, Linda Partridge
    Pages 105-124
  8. Carlos De Magalhaes Filho, Martin Holzenberger
    Pages 125-142
  9. Nir Barzilai, Derek M. Huffman, Pinchas Cohen, Radhika H. Muzumdar
    Pages 143-153
  10. Back Matter
    Pages 155-157

About this book

Introduction

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

Keywords

G proteins ageing cells genes growth growth factor growth hormone hormone insulin insulin-like metabolism muscle protein skeletal muscle tissue

Editors and affiliations

  • David Clemmons
    • 1
  • Iain C.A.F. Robinson
    • 2
  • Yves Christen
    • 3
  1. 1.Chapel HillUniversity of North CarolinaChapel HillU.S.A.
  2. 2.Lab. Endocrine PhysiologyNational Inst. Med. ResearchLondonUnited Kingdom
  3. 3.Recherche TherapeutiqueFondation IPSEN pour laBoulogne Billancourt CedexFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-04302-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-04301-7
  • Online ISBN 978-3-642-04302-4
  • Series Print ISSN 1861-2253
  • Buy this book on publisher's site