Death Receptors and Cognate Ligands in Cancer

  • Holger Kalthoff

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 49)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Harald Wajant
    Pages 1-15
  3. M. Lettau, M. Paulsen, D. Kabelitz, O. Janssen
    Pages 49-61
  4. Ken-ichi Fujita, Srinivasa M. Srinivasula
    Pages 87-114
  5. Stefanie M. Cordier, Kerstin Papenfuss, Henning Walczak
    Pages 115-143
  6. Fiona C. Kimberley, Jan Paul Medema, Michael Hahne
    Pages 161-182
  7. Shida Yousefi, Hans-Uwe Simon
    Pages 183-190
  8. Ingrid Herr, Markus W. Büchler, Jürgen Mattern
    Pages 191-218
  9. Olivier Niemöller, Claus Belka
    Pages 219-239
  10. Back Matter
    Pages 275-280

About this book

Introduction

Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events.

Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells.

This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.

Keywords

Immune System Immunity apoptosis cancer development cells death receptor signalling proteins regulation

Editors and affiliations

  • Holger Kalthoff
    • 1
  1. 1.Klinik für Allgemeine Chirurgie undUniversitätsklinikum Schleswig-HolsteinKielGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-03045-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-03044-4
  • Online ISBN 978-3-642-03045-1
  • Series Print ISSN 0080-1844
  • Series Online ISSN 1861-0412
  • About this book