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Behavioral Neuroscience of Drug Addiction

  • David W. Self
  • Julie K.  Staley Gottschalk

Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 3)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Garret D. Stuber, F. Woodward Hopf, Kay M. Tye, Billy T. Chen, Antonello Bonci
    Pages 3-27
  3. Ingo Willuhn, Matthew J. Wanat, Jeremy J. Clark, Paul E. M. Phillips
    Pages 29-71
  4. Deanne M. Buffalari, Ronald E. See
    Pages 73-99
  5. Heather C. Lasseter, Xiaohu Xie, Donna R. Ramirez, Rita A. Fuchs
    Pages 101-117
  6. Manoranjan S. D’Souza, Athina Markou
    Pages 119-178
  7. Louk J. M. J. Vanderschuren, R. Christopher Pierce
    Pages 179-195
  8. Kelly P. Cosgrove
    Pages 199-217
  9. Diana Martinez, Rajesh Narendran
    Pages 219-245
  10. Thomas Lundqvist
    Pages 247-275
  11. Daniel J. Müller, Olga Likhodi, Andreas Heinz
    Pages 277-299
  12. Robert Hester, Dan I. Lubman, Murat Yücel
    Pages 301-318
  13. Warren K. Bickel, Richard Yi, E. Terry Mueller, Bryan A. Jones, Darren R. Christensen
    Pages 319-341
  14. Ellen Edens, Alfredo Massa, Ismene Petrakis
    Pages 343-386
  15. Back Matter
    Pages 387-392

About this book

Introduction

Drug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal dev- tation. The disorder af?icts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain’s natural reward substrates, and that chronic drug use causes aberrant alterations in these rewa- processing systems. Such aberrations may be demonstrated at the cellular, neu- transmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chronic drug exposure. Behaviorally, these neural aberrations manifest as exaggerated, altered or dysfunctional expr- sion of learned behavioral responses related to the pursuit of drug rewards, or to environmental factors that precipitate craving and relapse during periods of drug withdrawal. Current research efforts are aimed at understanding the associative and causal relationships between these neurobiological and behavioral events, such that treatment options will ultimately employ therapeutic amelioration of neural de?cits and restoration of normal brain processing to promote efforts to abstain from further drug use. The Behavioral Neuroscience of Drug Addiction, part of the Springer series on Current Topics in Behavioral Neurosciences, contains scholarly reviews by noted experts on multiple topics from both basic and clinical neuroscience ?elds.

Keywords

Behavioral Neuroscience Neurobiology behavior cocaine dopamine drugs of abuse neuroimaging

Editors and affiliations

  • David W. Self
    • 1
  • Julie K.  Staley Gottschalk
    • 2
  1. 1.Southwestern Medical CenterUniversity of TexasDallasU.S.A.
  2. 2.School of MedicineYale UniversityWest HavenU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-03001-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-03000-0
  • Online ISBN 978-3-642-03001-7
  • Series Print ISSN 1866-3370
  • Series Online ISSN 1866-3389
  • Buy this book on publisher's site