HIV Interactions with Host Cell Proteins

1. Front Matter

   Pages 1-9

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2. Host Restriction of HIV-1 by APOBEC3 and Viral Evasion Through Vif

   • Anna Maria Niewiadomska, Xiao-Fang Yu

   Pages 1-25

3. Interactions of Viral protein U (Vpu) with Cellular Factors

   • John C. Guatelli

   Pages 27-45

4. TRIM5alpha

   • Byeongwoon Song

   Pages 47-66

5. Human Immunodeficiency Virus Type-1 Gag and Host Vesicular Trafficking Pathways

   • Hin Chu, Jaang-Jiun Wang, Paul Spearman

   Pages 67-84

6. The Roles of Tetraspanins in HIV-1 Replication

   • Markus Thali

   Pages 85-102

7. Imaging of HIV/Host Protein Interactions

   • Cindy M. Danielson, Thomas J. Hope

   Pages 103-123

8. Virological and Cellular Roles of the Transcriptional Coactivator LEDGF/p75

   • Manuel Llano, James Morrison, Eric M. Poeschla

   Pages 125-146

9. Implications of Nef: Host Cell Interactions in Viral Persistence and Progression to AIDS

   • Nathalie J. Arhel, Frank Kirchhoff

   Pages 147-175

10. Vpr and Its Interactions with Cellular Proteins

    • Vicente Planelles, Serge Benichou

    Pages 177-200

11. Back Matter

    Pages 1-4

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The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis. On the other side of the coin, virologists seek to de?ne those cellular elements interacting intimatelywiththeir virus ofinterestinorder to better understand viral replication itself, and in some cases to develop antiviral strategies. It is in the intersection of virology and cell biology that many of us ?nd the most rewarding aspects of our research. When a new discovery yields insights into basic cellular mechanisms and presents new targets for int- vention to ?ght a serious pathogen, the impact can be high and the excitement intense. HIV has been no exception to the rule that viruses reveal many basic aspects of cellular biology. In recent years, in part because of the importance of HIV as a major cause of human suffering, numerous cellular processes have been elucidated through work on processes or proteins of this human retrovirus. The excitement in this ?eld is especially well illustrated by the discovery of new innate means of resisting viral replication, such as the work on APOBEC3G, TRIM5a, and BST-2/ tetherin presented in this volume.

• AIDS
• HIV
• HIV-1 replication
• cellular vesicular trafficking
• imaging
• retroviral replication
• tetherin
• tetraspanins
• transcriptional coactivator
• vaccine
• viral immune evasion
• viral infectivity factor (Vif)
• virus

• School of Medicine, Dept. Pediatrics, Emory University, Atlanta, USA

  Paul Spearman

• HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, USA

  Eric O. Freed

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