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Adverse Drug Reactions

  • Book
  • © 2010


  • Provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs)
  • Main focus is on idiosyncratic drug reactions

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 196)

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About this book

This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal.

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Table of contents (19 chapters)

  1. Target Organ Toxicity

  2. Mediators/Biochemical Pathways

  3. Examples/Models

Editors and Affiliations

  • Faculty of Pharmacy, University of Toronto, Toronto, Canada

    Jack Uetrecht

Bibliographic Information

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