Recombination and Meiosis

Crossing-Over and Disjunction

  • Editors
  • Richard Egel
  • Dirk-Henner Lankenau

Part of the Genome Dynamics and Stability book series (GENOME, volume 2)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. José A. Suja, Julio S. Rufas
    Pages 31-56
  3. Koichi Tanaka, Yoshinori Watanabe
    Pages 57-79
  4. Sonam Mehrotra, R. Scott Hawley, Kim S. McKim
    Pages 125-151
  5. Celia A. May, M. Timothy Slingsby, Alec J. Jeffreys
    Pages 195-244
  6. Haris Kokotas, Maria Grigoriadou, Michael B. Petersen
    Pages 245-278
  7. Livia Pérez-Hidalgo, Sergio Moreno, Cristina Martín-Castellanos
    Pages 307-353
  8. Back Matter
    Pages 355-365

About this book


Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II – reducing chromosome number from the diploid level to a haploid genome, reshuffling the homologous chromosomes by their centromeres, and recombining chromosome arms by crossing-over. In animals, including humans, all this happens during the germ cell formation of eggs and sperm. Due to the reign of meiosis, no child is a true genetic copy of either parent. Central to mainstream meiosis, the mechanisms of reciprocal exchange at crossover/chiasma sites stand out as a controlled program of biologically significant molecular changes. To initiate the meiotic exchange of DNA, surgical cuts are made as a form of calculated damage that is subsequently repaired by homologous recombination. These key events are accompanied by ancillary provisions at the level of chromosome core organization, sister chromatid cohesion, and differential centromere connectivity. Great progress has been made in recent years to further our understanding of these mechanisms. Questions still open primarily concern the placement of and mutual coordination between neighboring crossover events. The current book addresses these processes and mechanisms in multicellular eukaryotes, such as Drosophila, Arabidopsis, mice and humans. The pioneering model systems of yeasts, as well as evolutionary aspects, will be addressed in a forthcoming volume.


Chromosom Chromosome Dysjunction DNA DNA Double Strand Breaks Homolog Synapsis Meiosis eukaryote evolution recombination regulation

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-75371-1
  • Online ISBN 978-3-540-75373-5
  • Series Print ISSN 1861-3373
  • Buy this book on publisher's site