Overview
- Includes supplementary material: sn.pub/extras
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 184)
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Table of contents (17 chapters)
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Front Matter
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Back Matter
Keywords
About this book
It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book’s second part, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process. These include ligand-gated ion channels and presynaptic G-protein-coupled receptors. The targets of presynaptic receptors within the exocytosis cascade, and their therapeutic potential, are subjects addressed in the majority of chapters.
Editors and Affiliations
Bibliographic Information
Book Title: Pharmacology of Neurotransmitter Release
Editors: Thomas C. Südhof, Klaus Starke
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-540-74805-2
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2008
Hardcover ISBN: 978-3-540-74804-5Published: 18 December 2007
Softcover ISBN: 978-3-642-09424-8Published: 22 November 2010
eBook ISBN: 978-3-540-74805-2Published: 07 December 2007
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: XIV, 582
Topics: Pharmacology/Toxicology, Neurosciences, Neurology, Human Physiology