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  • Book
  • © 2007

Molecular Genetics of Recombination

  • Covers one of the most important topics in modern biology: recombination

  • Summarize all existing views on the topic and to put them into context

  • In-depth and up-to-date analysis of the chapter topics, written by international experts

  • Includes supplementary material: sn.pub/extras

Part of the book series: Topics in Current Genetics (TCG, volume 17)

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eBook USD 389.00
Price excludes VAT (USA)
  • ISBN: 978-3-540-71021-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 499.99
Price excludes VAT (USA)
Hardcover Book USD 499.99
Price excludes VAT (USA)

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Table of contents (34 chapters)

  1. Front Matter

    Pages I-XXIV
  2. Genetics of recombination in the model bacterium Escherichia coli

    • Bénédicte Michel, Zeynep Baharoglu, Roxane Lestini
    Pages 1-26
  3. Genetics of Recombination in the Model Bacterium Escherichia Coli

    • Bénédicte Michel, Zeynep Baharoglu, Roxane Lestini
    Pages 1-26
  4. Homologous Recombination in Low dC + dG Gram-Positive Bacteria

    • Humberto Sanchez, Begoña Carrasco, Silvia Ayora, Juan C. Alonso
    Pages 27-52
  5. Homologous recombination in low dC + dG Gram-positive bacteria

    • Humberto Sanchez, Begoña Carrasco, Silvia Ayora, Juan C. Alonso
    Pages 27-52
  6. Mating-Type Switching in S. Pombe

    • Benoit Arcangioli, Laura Roseaulin, Allyson Holmes
    Pages 95-133
  7. Biochemistry of eukaryotic homologous recombination

    • Wolf-Dietrich Heyer
    Pages 95-133
  8. Biochemistry of Eukaryotic Homologous Recombination

    • Wolf-Dietrich Heyer
    Pages 95-133
  9. DNA helicases in recombination

    • Hannah L. Klein
    Pages 135-167
  10. DNA helicases in recombination

    • Hannah L. Klein
    Pages 135-167
  11. Holliday junction resolution

    • Matthew C. Whitby
    Pages 169-199
  12. Replication forks and replication checkpoints in repair

    • Dana Branzei, Marco Foiani
    Pages 201-219
  13. Holliday Junction Resolution

    • Matthew C. Whitby
    Pages 221-249
  14. Sister chromatid recombination

    • Felipe Cortés-Ledesma, Félix Prado, Andrés Aguilera
    Pages 221-249
  15. Mating-type switching in S. pombe

    • Benoit Arcangioli, Laura Roseaulin, Allyson Holmes
    Pages 251-283
  16. The Cell Biology of Mitotic Recombination in Saccharomyces Cerevisiae

    • Michael Lisby, Rodney Rothstein
    Pages 317-333

About this book

Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage, which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents. Until recently, much of our knowledge on the mechanisms of genetic recombination has come from studies of prokaryotic and simple eukaryotic fungal systems. However, these studies have now been significantly extended to mammals, such that a comparative picture of the general factors and mechanisms of genetic recombination is beginning to emerge. Detailed genetic and biochemical studies have led to the isolation and characterization of many of the recombination-repair proteins in E. coli and S. cerevisiae, which in turn has led to the identification of homologues in human cells. The link between recombination defects and recombination proteins in a number of tumors as well as in human hereditary syndromes makes genetic recombination a cellular process of key importance not only in basic biology but also in biomedical studies.

Keywords

  • DNA
  • Double-strand break Repair
  • Escherichia coli
  • Genome Instability
  • biochemistry
  • cell biology
  • conservation
  • genetics
  • metabolism
  • protein
  • proteins
  • recombination
  • regulation
  • saccharomyces cerevisiae
  • transcription

Editors and Affiliations

  • Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, CSIC-Universidad de Sevilla, Sevilla, Spain

    Andrés Aguilera

  • Department of Genetics & Development, Columbia University Medical Center, New York, USA

    Rodney Rothstein

Bibliographic Information

Buying options

eBook USD 389.00
Price excludes VAT (USA)
  • ISBN: 978-3-540-71021-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 499.99
Price excludes VAT (USA)
Hardcover Book USD 499.99
Price excludes VAT (USA)