Viruses and Nanotechnology

1. Front Matter

   Pages i-x

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2. Chemical Modification of Viruses and Virus-Like Particles

   • E. Strable, M. G. Finn

   Pages 1-21

3. Structure-Based Engineering of an Icosahedral Virus for Nanomedicine and Nanotechnology

   • N. F. Steinmetz, T. Lin, G. P. Lomonossoff, J. E. Johnson

   Pages 23-58

4. Hybrid Assembly of CPMV Viruses and Surface Characteristics of Different Mutants

   • N. G. Portney, G. Destito, M. Manchester, M. Ozkan

   Pages 59-69

5. A Library of Protein Cage Architectures as Nanomaterials

   • M. L. Flenniken, M. Uchida, L. O. Liepold, S. Kang, M. J. Young, T. Douglas

   Pages 71-93

6. Biomedical Nanotechnology Using Virus-Based Nanoparticles

   • G. Destito, A. Schneemann, M. Manchester

   Pages 95-122

7. Tumor Targeting Using Canine Parvovirus Nanoparticles

   • P. Singh

   Pages 123-141

8. Back Matter

   Pages 143-147

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Nanotechnology is a collective term describing a broad range of relatively novel topics. Scale is the main unifying theme, with nanotechnology being concerned with matter on the nanometer scale. A quintessential tenet of nanotechnology is the precise self-assembly of nanometer-sized components into ordered devices. Nanotechnology seeks to mimic what nature has achieved, with precision at the nanometer level down to the atomic level. Nanobiotechnology, a division of nanotechnology, involves the exploitation of biomaterials, devices or methodologies in the nanoscale. In recent years a set of b- molecules has been studied and utilized. Virus particles are natural nanomaterials and have recently received attention for their tremendous potential in this field. The extensive study of viruses as pathogens has yielded detailed knowledge about their biological, genetic, and physical properties. Bacterial viruses (bacte- ophages), plant and animal eukaryotic viruses, and viruses of archaea have all been characterized in this manner. The knowledge of their replicative cycles allows manipulation and tailoring of particles, relying on the principles of self-assembly in infected hosts to build the base materials. The atomic resolution of the virion structure reveals ways in which to tailor particles for higher-order functions and assemblies.

• Nanomaterial
• bacteriophages
• biomedical imaging
• biotechnology
• cowpea mosaic virus
• design
• fabrication
• flock house virus
• icosahedral virus
• nanotechnology
• protein
• protein cage architectures
• viral nanoparticles
• virus
• virus-like particles

• Department of Cell Biology Center for Integrative Molecular Biosciences, Scripps Research Institute, La Jolla, USA

  Marianne Manchester, Nicole F. Steinmetz